Usami S, Hozawa J, Tazawa M, Yoshihara T, Igarashi M, Thompson G C
Department of Otorhinolaryngology, Hirosaki University School of Medicine, Japan.
Acta Otolaryngol Suppl. 1988;447:36-45. doi: 10.3109/00016488809102855.
The enzymes for synthesis of catecholamine, tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyl transferase (PNMT), have been immunocytochemically localized in the guinea pig cochlea. Two groups of catecholamine-containing neurons could be distinguished. The first group, which was TH-positive/DBH, PNMT-negative, was found in the inner spiral bundle and the tunnel spiral bundle. The other group was TH, DBH-positive/PNMT-negative, and was found around the blood vessels. The immunocytochemical evidence obtained in this experiment suggests that the catecholamines should play a functional role in the guinea pig cochlea.
儿茶酚胺合成酶，即酪氨酸羟化酶（TH）、多巴胺β-羟化酶（DBH）和苯乙醇胺N-甲基转移酶（PNMT），已通过免疫细胞化学方法定位在豚鼠耳蜗中。可区分出两组含儿茶酚胺的神经元。第一组为TH阳性/DBH阳性、PNMT阴性，位于内螺旋束和隧道螺旋束中。另一组为TH、DBH阳性/PNMT阴性，位于血管周围。本实验获得的免疫细胞化学证据表明，儿茶酚胺在豚鼠耳蜗中应发挥功能性作用。
