Department of Pharmaceutical Analysis, Faculty of Pharmacy, Fujian Medical University, Fuzhou 350108, Fujian, China.
Department of Pharmacy, Pharmacy and Medical Technology School, Putian University, Putian 351100, Fujian, China.
Cancer Biomark. 2017 Dec 6;20(4):357-367. doi: 10.3233/CBM-170258.
Pancreatic cancers with poor prognosis are highly malignant, readily metastatic and of immune tolerance, mainly due to delayed detection. The metastatic progression and immune tolerance of pancreatic cancer is greatly attributed to the intercellular communication. However, exosomes are deemed to be the most important tool of intercellular communicators. Thus, we present a review of pancreatic cancer and exosomes in this article. We intensively summarize the progress of early pancreatic cancer and the relationship of the proliferation, progression and metastasis of pancreatic cancer and pancreatic cancer-derived exosomes, and propose new ideas of the study of pancreatic cancer.
预后不良的胰腺癌恶性程度高、易转移且具有免疫耐受，这主要是由于检测延迟所致。胰腺癌的转移进展和免疫耐受在很大程度上归因于细胞间通讯。然而，外泌体被认为是细胞间通讯最重要的工具。因此，我们在本文中对胰腺癌和外泌体进行了综述。我们深入总结了早期胰腺癌的进展以及胰腺癌和胰腺癌衍生的外泌体的增殖、进展和转移之间的关系，并提出了胰腺癌研究的新思路。
