Department of Surgery, Universitätsklinikum Erlangen, Krankenhausstraße 12, 91054 Erlangen, Germany.
Int J Mol Sci. 2019 Sep 4;20(18):4332. doi: 10.3390/ijms20184332.
Pancreatic cancer remains one of the deadliest cancers in the world, as a consequence of late diagnosis, early metastasis and limited response to chemotherapy, under which conditions the potential mechanism of pancreatic cancer progression requires further study. Exosomes are membrane vesicles which are important in the progression, metastasis and chemoresistance in pancreatic cancer. Additionally, they have been verified to be potential as biomarkers, targets and drug carriers for pancreatic cancer treatment. Thus, studying the role of exosomes in pancreatic cancer is significant. This paper focuses on the role of exosomes in the proliferation, metastasis and chemoresistance, as well as their potential applications for pancreatic cancer.
胰腺癌仍然是世界上最致命的癌症之一，其原因是诊断较晚、早期转移和对化疗的反应有限，在这种情况下，胰腺癌进展的潜在机制需要进一步研究。外泌体是一种膜囊泡，在胰腺癌的进展、转移和化疗耐药中起重要作用。此外，它们已被证明是胰腺癌治疗的潜在生物标志物、靶点和药物载体。因此，研究外泌体在胰腺癌中的作用具有重要意义。本文重点介绍了外泌体在胰腺癌增殖、转移和化疗耐药中的作用及其在胰腺癌治疗中的潜在应用。
