Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model.

BACKGROUND

Certain diseases can occur with and without a trigger. We use Venous Thromboembolism (VTE) as our example to identify genetic interaction with pregnancy in women with VTE during pre- or postpartum. Pregnancy is one of the major risk factors for VTE as it accounts for 10% of maternal deaths.

METHODS

We performed a whole genome association analysis using the Cox Proportional Hazard (CoxPH) model adjusted for covariates to identify genetic variants associated with the time-to-event of VTE related to pre- or postpartum during the childbearing age of 18-45 years using a case-only design in a cohort of women with VTE. Women with a VTE event after 45 years of age were censored and contributed only follow-up time.

RESULTS

We identified two intragenic single nucleotide polymorphisms (SNPs) at genome-wide significance in the gene located on chromosome 7, and two additional intragenic SNPs, one in the gene on chromosome 9 and one in on chromosome X.

CONCLUSIONS

We showed that the time-to-event model is a useful approach for identifying potential hazard-modification of the genetic variants when the event of interest (VTE) occurs due to a risk factor (pre- or post-partum).