Zhang Y Z, Yu Y Q, Yuan Y, He M A, Wu T C
School of Public Health, TongJi Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2017 Oct 6;51(10):922-926. doi: 10.3760/cma.j.issn.0253-9624.2017.10.010.
To investigate the association between alcohol use and incidence of type 2 diabetes mellitus (T2DM) in the middle-aged and elderly male population. All participants were from Dongfeng-Tongji cohort, 27 009 retired employees from Dongfeng Motor Corporation in Hubei Province were enrolled in the Dongfeng-Tongji cohort baseline survey in 2008. In baseline study, information of alcohol use and other covariates were collected by semi-structured questionnaire and all participants completed physical examination including the test of fasting glucose and blood lipid levels. A total of 6 784 male participants from Dongfeng-Tongji cohort who were without diagnosis of diabetes, coronary heart disease, stroke, or cancer in baseline study were enrolled in this study. We completed the first follow-up in 2013 and the outcome of disease or death was retrieved based on health-care medical records according to the unique medical insurance ID. Cox proportional hazard regression model was used to estimate the association between alcohol use and incidence of type 2 diabetes mellitus (T2DM), by drinking features and patterns. Out of the 6 784 participants, 3 541 participant were defined as non-alcohol drinkers and there were 15 852.2 person-years of follow-up; among which 270 new cases of T2DM were diagnosed withthe crude incidence density of non-alcohol drinkers at 1 703.2/100 000 person-years. The other 3 243 subjects were classified as alcohol drinkers and there were 14 509.8 person-years of follow-up; and among which 258 new cases of T2DM were diagnosed, with the crude incidence density of T2DM at 1 778.1/100 000 person-years. Multivariate COX proportional hazard regression model indicated that there was no significantly increased risk of T2DM incidence between alcohol drinkers and non-alcohol drinkers((95): 1.09 (0.91- 1.30)). However, participants who averagely consumed >20 g/d or7 times/week had a significantly increased risk of T2DM compared with non-alcohol drinkers, and the value of (95) was 1.27 (1.02- 1.58) and 1.35 (1.00- 1.83), respectively. Among men who consumed alcoholic beverages more than 7 times/week, (95) for T2DM incidence in the subjects who consumed 0.01 to 40 g and > 40 g once a time were 1.48 (1.05- 2.09) and 1.27 (0.80- 2.10), respectively. Although we found no relationship between alcohol use and T2DM incidence overall, alcohol use more than 20 g/d or more than 7 times/week would increase the risk of T2DM.
探讨中老年男性人群饮酒与2型糖尿病（T2DM）发病率之间的关联。所有参与者均来自东风-同济队列，2008年，来自湖北省东风汽车公司的27009名退休员工参加了东风-同济队列基线调查。在基线研究中，通过半结构化问卷收集饮酒及其他协变量信息，所有参与者均完成了包括空腹血糖和血脂水平检测在内的体格检查。本研究纳入了东风-同济队列中6784名在基线研究时未诊断出糖尿病、冠心病、中风或癌症的男性参与者。我们在2013年完成了首次随访，并根据唯一的医疗保险ID，依据医疗保健病历检索疾病或死亡结局。采用Cox比例风险回归模型，按饮酒特征和模式估计饮酒与2型糖尿病（T2DM）发病率之间的关联。在6784名参与者中，3541名参与者被定义为不饮酒者，随访人年数为15852.2人年；其中270例新诊断为T2DM，不饮酒者的粗发病率密度为1703.2/100000人年。另外3243名受试者被归类为饮酒者，随访人年数为14509.8人年；其中258例新诊断为T2DM，T2DM的粗发病率密度为1778.1/100000人年。多变量COX比例风险回归模型表明，饮酒者和不饮酒者之间T2DM发病风险没有显著增加（(95)：1.09(0.91 - 1.30)）。然而，与不饮酒者相比，平均每日饮酒量>20g或每周饮酒7次以上的参与者患T2DM的风险显著增加，(95)值分别为1.27(1.02 - 1.58)和1.35(1.00 - 1.83)。在每周饮酒次数超过７次的男性中，单次饮酒量为0.01至40g和>40g的受试者T2DM发病的(95)值分别为1.48(1.05 - 2.09)和1.27(0.80 - 2.10)。虽然我们总体上未发现饮酒与T2DM发病率之间存在关联，但每日饮酒量超过20g或每周饮酒次数超过7次会增加患T2DM的风险。
