Hôpital Européen Georges Pompidou, APHP, Unité de Parasitologie-Mycologie, Service de Microbiologie, Paris, France.
Université Pierre et Marie Curie, Paris VI, Paris, France.
Antimicrob Agents Chemother. 2017 Dec 21;62(1). doi: 10.1128/AAC.01382-17. Print 2018 Jan.
combinations of isavuconazole with echinocandins were evaluated against 30 strains with a two-dimensional checkerboard microdilution method and an agar-based diffusion method. With the checkerboard method, the three combinations showed indifferent interactions for all strains. With the agar-based method, indifferent interactions were found for all strains for isavuconazole-micafungin and isavuconazole-anidulafungin. For the isavuconazole-caspofungin combination, indifference was found in 24/30 strains, synergism in 4/30 strains, and antagonism in 2/30 strains.
采用二维棋盘微量稀释法和琼脂扩散法评估了伊曲康唑与棘白菌素类药物联合用药的效果，共评估了 30 株菌株。采用棋盘微量稀释法，三种联合用药对所有菌株均表现为无关作用。采用琼脂扩散法，伊曲康唑-米卡芬净和伊曲康唑-阿尼芬净对所有菌株均表现为无关作用。对于伊曲康唑-卡泊芬净的联合用药，在 30 株菌株中发现 24 株为无关作用，4 株为协同作用，2 株为拮抗作用。
