周期性服用西地那非对勃起功能障碍患者眼压的影响。

Effect of periodic sildenafil dosage on intraocular pressure in patients with erectile dysfunction.

作者信息

Nazari Alireza, Tabrizi Yousof Taghavi, Mokhtaree Mohammadreza

机构信息

M.D. Urologist, Assistant Professor, Department of Surgery, Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

M.D. Ophthalmologist, Assistant Professor, Department of Ophthalmology and Otorhinolaryngology, Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

出版信息

Electron Physician. 2017 Sep 25;9(9):5229-5232. doi: 10.19082/5229. eCollection 2017 Sep.

DOI:10.19082/5229

PMID:29038701

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5633217/

Abstract

BACKGROUND AND AIM

Sildenafil is used to treat erectile dysfunction but it has association with some side effects. This study was conducted with the aim of investigating the effect of duration of taking sildenafil on intraocular pressure (IOP) in patients with erectile dysfunction.

METHODS

The study population of this cross-sectional study were all males with erectile dysfunction referring to the urology clinic affiliated to Rafsanjan University of Medical Sciences (Kerman, Iran) over a one-year period (2015-2016) among whom 110 patients were included in the study. After medical examinations and required investigations, a weekly dose of 25-100mg sildenafil (50 mg per week on average) was prescribed for patients. IOP in these patients was measured by an ophthalmologist before, one month after and three months after taking medication respectively. Finally, data were analyzed by SPSS version 16 using repeated measures test.

RESULTS

Mean IOP before taking medication as well as one month and three months after taking sildenafil was 14.88±1.3, 15±1.28 and 15±1.34 mmHg respectively. Analysis of results showed that the difference in IOP in various periods of measurement was significant (p<0.001). Mean IOP before taking sildenafil was significantly different from three months after taking it (p<0.001) and mean IOP one month after taking sildenafil was significantly different from three months after taking it (p=0.002).

CONCLUSION

Results of this study indicated that taking sildenafil for three months increased IOP. Although these changes may not be clinically significant.

摘要

背景与目的

西地那非用于治疗勃起功能障碍，但它与一些副作用有关。本研究旨在调查服用西地那非的时长对勃起功能障碍患者眼压（IOP）的影响。

方法

本横断面研究的研究对象为在一年期间（2015 - 2016年）前往拉夫桑詹医科大学（伊朗克尔曼）附属泌尿外科诊所就诊的所有勃起功能障碍男性患者，其中110例患者纳入研究。经过医学检查和必要的调查后，为患者开具每周25 - 100毫克西地那非（平均每周50毫克）的剂量。这些患者的眼压分别在服药前、服药后1个月和3个月由眼科医生测量。最后，使用SPSS 16版软件通过重复测量检验对数据进行分析。

结果

服用西地那非前、服药1个月和3个月后的平均眼压分别为14.88±1.3、15±1.28和15±1.34毫米汞柱。结果分析表明，不同测量时期的眼压差异具有统计学意义（p<0.001）。服用西地那非前的平均眼压与服药3个月后的平均眼压差异有统计学意义（p<0.001），服用西地那非1个月后的平均眼压与服药3个月后的平均眼压差异有统计学意义（p = 0.002）。