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[儿童及青少年多发性硬化症:复杂、慢性且具有差异性]

[Multiple sclerosis in childhood and adolescence : Complex, chronic and differentiated].

作者信息

Blaschek A, Huppke P, Kümpfel T, Müller-Felber W, Rostasy K

机构信息

Pädiatrische Neurologie, Zentrum für neuromuskuläre Erkrankungen und Neuroimmunologie im Kindesalter, LMU Zentrum - iSPZ Hauner, Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital, Universität München, München, Deutschland.

Abteilung Pädiatrische Neurologie, Entwicklungsneurologie und Sozialpädiatrie, Dr. von Haunersches Kinderspital, Ludwig-Maximilians-Universität München, Lindwurmstraße 4, 80337, München, Deutschland.

出版信息

Nervenarzt. 2017 Dec;88(12):1377-1384. doi: 10.1007/s00115-017-0422-z.

DOI:10.1007/s00115-017-0422-z
PMID:29038883
Abstract

Pediatric multiple sclerosis (MS) is one of the most important acquired neurological disorders in childhood and adolescence. A timely recognition, diagnosis and treatment are of utmost importance. This article highlights the current state of knowledge on the etiology, pathogenesis, diagnosis, clinical presentation and treatment in childhood. Although the rate of progression of disability in the early years is slower in younger patients compared to adults, a disease-modifying therapy should be started once MS is diagnosed.

摘要

小儿多发性硬化症(MS)是儿童和青少年时期最重要的后天性神经系统疾病之一。及时识别、诊断和治疗至关重要。本文重点介绍了儿童MS在病因、发病机制、诊断、临床表现和治疗方面的当前知识状况。尽管与成人相比,年轻患者在疾病早期的残疾进展速度较慢,但一旦确诊MS,就应开始使用疾病修正疗法。

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1
[Multiple sclerosis in childhood and adolescence : Complex, chronic and differentiated].[儿童及青少年多发性硬化症:复杂、慢性且具有差异性]
Nervenarzt. 2017 Dec;88(12):1377-1384. doi: 10.1007/s00115-017-0422-z.
2
Update on multiple sclerosis.多发性硬化症的最新进展。
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Brain Behav. 2015 Sep;5(9):e00362. doi: 10.1002/brb3.362. Epub 2015 Aug 3.
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Pediatric multiple sclerosis.小儿多发性硬化症
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本文引用的文献

1
Prognostic relevance of MOG antibodies in children with an acquired demyelinating syndrome.MOG抗体在获得性脱髓鞘综合征患儿中的预后相关性。
Neurology. 2017 Aug 29;89(9):900-908. doi: 10.1212/WNL.0000000000004312. Epub 2017 Aug 2.
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Differential diagnosis and evaluation in pediatric inflammatory demyelinating disorders.儿童炎性脱髓鞘疾病的鉴别诊断与评估
Neurology. 2016 Aug 30;87(9 Suppl 2):S28-37. doi: 10.1212/WNL.0000000000002878.
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Fingolimod Prescribed for the Treatment of Multiple Sclerosis in Patients Younger Than Age 18 Years.
芬戈莫德被用于治疗18岁以下患者的多发性硬化症。
Pediatr Neurol. 2015 Aug;53(2):166-8. doi: 10.1016/j.pediatrneurol.2015.03.024. Epub 2015 Apr 2.
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Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses.环境风险因素与多发性硬化症:系统评价和荟萃分析的伞状综述。
Lancet Neurol. 2015 Mar;14(3):263-73. doi: 10.1016/S1474-4422(14)70267-4. Epub 2015 Feb 4.
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Multiple sclerosis in children: an update on clinical diagnosis, therapeutic strategies, and research.儿童多发性硬化症:临床诊断、治疗策略和研究的最新进展。
Lancet Neurol. 2014 Sep;13(9):936-48. doi: 10.1016/S1474-4422(14)70093-6.
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Clinical and neuroradiological differences of paediatric acute disseminating encephalomyelitis with and without antibodies to the myelin oligodendrocyte glycoprotein.具有和不具有髓鞘少突胶质细胞糖蛋白抗体的小儿急性播散性脑脊髓炎的临床和神经影像学差异。
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JC virus antibody status in a pediatric multiple sclerosis cohort: prevalence, conversion rate and influence on disease severity.儿童多发性硬化症队列中的JC病毒抗体状态:患病率、转化率及其对疾病严重程度的影响。
Mult Scler. 2015 Apr;21(4):382-7. doi: 10.1177/1352458514543340. Epub 2014 Jul 28.
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Multiple sclerosis in children and adolescents: incidence and clinical picture - new insights from the nationwide German surveillance (2009-2011).儿童和青少年多发性硬化症:发病率和临床特征-来自全国性德国监测(2009-2011)的新见解。
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9
Clinical presentation of pediatric multiple sclerosis before puberty.儿童多发性硬化症青春期前的临床表现。
Eur J Neurol. 2014 Mar;21(3):441-6. doi: 10.1111/ene.12327. Epub 2013 Dec 16.
10
Risk genes associated with pediatric-onset MS but not with monophasic acquired CNS demyelination.与儿科发病型多发性硬化症相关但与单相获得性中枢神经系统脱髓鞘病变无关的风险基因。
Neurology. 2013 Dec 3;81(23):1996-2001. doi: 10.1212/01.wnl.0000436934.40034eb. Epub 2013 Nov 6.