Aarseth H P, Bredesen J E, Grynne B, Lyngdal P T, Storstein L, Wiik-Larsen E
Department of clinical Pharmacology, Ullevål Hospital, Oslo, Norway.
J Toxicol Clin Toxicol. 1988;26(5-6):283-92. doi: 10.1080/15563658809167093.
In a double blind study including 18 patients in whom a benzodiazepine intoxication was suspected, the first specific benzodiazepine antagonist was compared to placebo. There was a highly significant effect on consciousness, all patients given antagonist awaked, usually within minutes. No adverse effects were observed. In 2 patients the clinical condition deteriorated 1 to 2 hrs after the antagonist was given. This might endanger intoxicated patients withdrawing from medical attention.
在一项双盲研究中，纳入了18名疑似苯二氮䓬中毒的患者，将第一种特异性苯二氮䓬拮抗剂与安慰剂进行了比较。该拮抗剂对意识有非常显著的影响，所有给予拮抗剂的患者均苏醒，通常在数分钟内。未观察到不良反应。在2名患者中，给予拮抗剂后1至2小时临床状况恶化。这可能会危及那些未接受医疗护理的中毒患者。
