Doi Atsushi, Miyamoto Kazuaki, Nakano Yu-Shin, Sakasaki Juntaro, Kasae Syota, Nishimura Keisuke, Shin Min-Chul, Yoshimura Megumu
Department of Rehabilitation, Kumamoto Health Science University, Kumamoto, Kumamoto, Japan.
Graduate School of Health Science, Kumamoto Health Science University, Kumamoto, Kumamoto, Japan.
PLoS One. 2017 Oct 17;12(10):e0186189. doi: 10.1371/journal.pone.0186189. eCollection 2017.
We investigated the effects of a vibratory stimulus on the plantar surface of the hind limb for motor, sensory, and locomotive function using a mouse cast model. The right knee joint of C57BL/6 male mice (7 weeks, 20 g, n = 31) was flexed with aluminum splint and tape for 6 weeks. These mice were randomly divided into 2 groups (control group, n = 11 and vibration group, n = 12). The mice in the vibration group received vibration on the sole of the ankle for 15 minutes per day, 5 days per week. After the knee joint cast was removed, we measured the range of motion (ROM) of both knee and ankle joints and the sensory threshold of the sole. Further, both walking and swimming movements were analyzed with a digital video. The sole vibration did not affect the passive ROM of the knee joint and sensory threshold after cast removal. However, it increased the ankle dorsiflexion range and improved free walking, swimming, and active movement of the knee joint. In conclusion, we show that the vibration recovered both walking and swimming movements, which resulted from improvements in both the passive ankle dorsiflexion and active knee movement.
我们使用小鼠石膏模型研究了对后肢足底表面施加振动刺激对运动、感觉和 locomotive 功能的影响。将 C57BL/6 雄性小鼠（7 周龄，20 g，n = 31）的右膝关节用铝夹板和胶带屈曲固定 6 周。这些小鼠被随机分为两组（对照组，n = 11；振动组，n = 12）。振动组的小鼠每天在踝关节底部接受 15 分钟的振动，每周 5 天。去除膝关节石膏后，我们测量了膝关节和踝关节的活动范围（ROM）以及足底的感觉阈值。此外，使用数字视频分析了行走和游泳运动。足底振动在去除石膏后不影响膝关节的被动 ROM 和感觉阈值。然而，它增加了踝关节背屈范围，并改善了自由行走、游泳以及膝关节的主动运动。总之，我们表明振动恢复了行走和游泳运动，这是由于被动踝关节背屈和主动膝关节运动均得到改善所致。
