Nakamura T, Ide H, Eguchi R, Hayashi K, Takasaki K, Watanabe S
Department of Surgery, Institute of Gastroenterology Kawada-cho 8-1, Shinjuku-ku, Tokyo 162, Japan.
Department of Clinical Laboratory, Tokyo Women's Medical College, Kawada-cho 8-1, Shinjuku-ku, Tokyo 162, Japan.
Dis Esophagus. 2017 Nov 1;11(1):35-39. doi: 10.1093/dote/11.1.35.
This study assessed the clinical value of CYFRA 21-1 in comparison with squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) in patients with esophageal squamous cell carcinoma. In 112 primary cancer patients, the diagnostic sensitivity of CYFRA 21-1 (33.9%) was superior to SCC-Ag (28.6%), CEA (12.5%), and CA19-9 (6.3%). Levels of CYFRA 21-1 were closely correlated with TNM stage and were below the cutoff value in all 21 patients with stage I disease. All 38 patients with a CYFRA 21-1 level over the cutoff value among the 80 patients who underwent esophagectomy had lymph node metastases (pNl). A correlation was found between CYFRA 21-1 levels and clinical response in serial measurements of 21 patients who received chemotherapy or chemo radiotherapy. Our findings suggest that CYFRA 21-1 is not useful for diagnosis, but that it is valuable for monitoring the efficacy of therapy.
本研究评估了细胞角蛋白19片段（CYFRA 21-1）与鳞状细胞癌抗原（SCC-Ag）、癌胚抗原（CEA）和糖类抗原19-9（CA19-9）相比，在食管鳞状细胞癌患者中的临床价值。在112例原发性癌症患者中，CYFRA 21-1的诊断敏感性（33.9%）高于SCC-Ag（28.6%）、CEA（12.5%）和CA19-9（6.3%）。CYFRA 21-1水平与TNM分期密切相关，在所有21例I期疾病患者中均低于临界值。在80例行食管切除术的患者中，CYFRA 21-1水平超过临界值的38例患者均有淋巴结转移（pNl）。在21例接受化疗或放化疗的患者的连续测量中，发现CYFRA 21-1水平与临床反应之间存在相关性。我们的研究结果表明，CYFRA 21-1对诊断无帮助，但对监测治疗疗效有价值。
