血浆置换治疗感染性心内膜炎中免疫复合物介导的肾小球肾炎：病例报告及文献综述

Plasmapheresis for treatment of immune complex-mediated glomerulonephritis in infective endocarditis: a case report and literature review.

作者信息

Halpin Meredith, Kozyreva Olga, Bijol Vanesa, Jaber Bertrand L

机构信息

Department of Medicine, Division of Nephrology, St. Elizabeth's Medical Center.

Department of Medicine, Tufts University School of Medicine.

出版信息

Clin Nephrol Case Stud. 2017 Apr 13;5:26-31. doi: 10.5414/CNCS109082. eCollection 2017.

DOI:10.5414/CNCS109082

PMID:29043144

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5438014/

Abstract

We report the case of a 57-year-old man who presented with subacute bacterial endocarditis secondary to complicated by biopsy-proven immune complex-mediated glomerulonephritis (ICGN). Despite initial treatment with antibiotics and a short course of corticosteroids, the kidney function further deteriorated, and plasmapheresis was introduced as third-line therapy to remove circulating immune complexes. Following 7 treatment sessions, the patient recovered kidney function. We discuss the potential merit of plasmapheresis for patients with subacute bacterial endocarditis who develop ICGN.

摘要

我们报告了一例57岁男性患者的病例，该患者患有继发于活检证实的免疫复合物介导的肾小球肾炎（ICGN）的亚急性细菌性心内膜炎。尽管最初使用抗生素和短期皮质类固醇进行治疗，但肾功能仍进一步恶化，于是引入血浆置换作为三线治疗以清除循环免疫复合物。经过7次治疗后，患者肾功能恢复。我们讨论了血浆置换对于发生ICGN的亚急性细菌性心内膜炎患者的潜在益处。