Abbiyesuku Fayefori M, Agbakwuru Augustine N, Olawale Olatunbosun O
Department of Chemical Pathology, University College Hospital, Ibadan Nigeria.
Afr J Lab Med. 2013 Jul 24;2(1):44. doi: 10.4102/ajlm.v2i1.44. eCollection 2013.
Epidemiological studies have shown that sex hormone-binding globulin (SHBG) has a role in glucose homeostasis in both men and women. However, a prospective study on Japanese-American subjects concluded that SHBG was not a significant risk factor in either men or women, suggesting ethnic differences. We were not aware of any evaluation of SHBG in subjects of African ancestry.
We investigated the association between SHBG and insulin resistance in type 2 diabetic diabetic men in a hospital in Nigeria.
Forty-eight male subjects with type 2 diabetes and 20 non-diabetic male subjects were recruited in this cross-sectional hospital-based study by the convenient sampling method. Height and circumferences around the waist and hip were measured to the nearest 0.5 cm and the waist-hip ratio was calculated from this measurement. Weight was measured and body mass index was calculated. Fasting plasma glucose concentration was measured by the glucose oxidase method with a between-run coefficient of variation of 3%. Insulin and SHBG were measured by means of enzyme-linked immunosorbent assay (ELISA).
There was a statistically-significant difference between test results for the diabetic and non-diabetic patients. The mean SHBG concentration was higher in the non-diabetic group (42.2 nmol/L) than the diabetic group (30.5 nmol/L). A significant inverse association between insulin resistance and SHBG was observed ( = 0.353, < 0.015).
This study supported earlier observations that a significant inverse correlation exists between SHBG and insulin resistance and provides evidence that the relationship may extend to type 2 diabetic men of African ancestry in Nigeria.
流行病学研究表明，性激素结合球蛋白（SHBG）在男性和女性的葡萄糖稳态中均发挥作用。然而，一项针对日裔美国人的前瞻性研究得出结论，SHBG在男性或女性中均不是显著的风险因素，这表明存在种族差异。我们未发现对非洲裔受试者中SHBG的任何评估。
我们在尼日利亚一家医院调查了2型糖尿病男性患者中SHBG与胰岛素抵抗之间的关联。
在这项基于医院的横断面研究中，采用方便抽样法招募了48名2型糖尿病男性受试者和20名非糖尿病男性受试者。身高以及腰围和臀围测量精确到最接近的0.5厘米，并据此计算腰臀比。测量体重并计算体重指数。采用葡萄糖氧化酶法测量空腹血糖浓度，批间变异系数为3%。采用酶联免疫吸附测定（ELISA）法测量胰岛素和SHBG。
糖尿病患者和非糖尿病患者的检测结果存在统计学显著差异。非糖尿病组的平均SHBG浓度（42.2 nmol/L）高于糖尿病组（30.5 nmol/L）。观察到胰岛素抵抗与SHBG之间存在显著的负相关（ = 0.353， < 0.015）。
本研究支持了早期的观察结果，即SHBG与胰岛素抵抗之间存在显著的负相关，并提供了证据表明这种关系可能延伸至尼日利亚非洲裔的2型糖尿病男性。
