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一名肾移植受者粟粒性肺结核的尸检结果

Autopsy findings of miliary tuberculosis in a renal transplant recipient.

作者信息

Shergill Khushdeep, Shelly Divya, G Manoj, Kumar Ritu Ranjan

机构信息

Maharashtra University of Health Sciences, Armed Forces Medical College, Department of Pathology. Pune, Maharashtra, India.

出版信息

Autops Case Rep. 2017 Sep 30;7(3):7-12. doi: 10.4322/acr.2017.026. eCollection 2017 Jul-Sep.

DOI:10.4322/acr.2017.026
PMID:29043204
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5634428/
Abstract

Miliary tuberculosis is a lethal form of disseminated tuberculosis (TB), deriving its name from the millet-seed-sized granulomas in multiple organs. As TB still remains a leading cause of morbidity and mortality in India, its disseminated forms need to be diagnosed early to ensure more aggressive treatment at the earliest possible time. However, a considerable number of cases are missed ante-mortem. We discuss the case of a 32-year-old immunocompromised, non-HIV patient with an ante-mortem diagnosis of pulmonary TB. However, multiple organ involvement by was demonstrated on autopsy. This case highlights the role of autopsy as a research and learning tool, and prudential clinico-pathologic correlation, which will improve clinical outcomes in the future.

摘要

粟粒性肺结核是播散性肺结核的一种致命形式,因其在多个器官中出现粟粒大小的肉芽肿而得名。由于肺结核在印度仍然是发病和死亡的主要原因之一,其播散形式需要尽早诊断,以便尽早进行更积极的治疗。然而,相当多的病例在生前被漏诊。我们讨论了一名32岁免疫功能低下、非HIV患者的病例,该患者生前被诊断为肺结核。然而,尸检显示多个器官受累。该病例凸显了尸检作为一种研究和学习工具的作用,以及审慎的临床病理相关性,这将在未来改善临床结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/d9e9094c0485/autopsy-07-03007-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/4d841d280e4c/autopsy-07-03007-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/d31a63cbfeae/autopsy-07-03007-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/ec896a61dc84/autopsy-07-03007-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/97d4fb8a525d/autopsy-07-03007-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/4c9645d455c3/autopsy-07-03007-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/d9e9094c0485/autopsy-07-03007-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/4d841d280e4c/autopsy-07-03007-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/d31a63cbfeae/autopsy-07-03007-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/ec896a61dc84/autopsy-07-03007-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/97d4fb8a525d/autopsy-07-03007-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/4c9645d455c3/autopsy-07-03007-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/5634428/d9e9094c0485/autopsy-07-03007-g06.jpg

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本文引用的文献

1
Miliary Tuberculosis.肺结核。
Microbiol Spectr. 2017 Mar;5(2). doi: 10.1128/microbiolspec.TNMI7-0013-2016.
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Tuberculosis 2015: Burden, Challenges and Strategy for Control and Elimination.《2015年结核病:负担、挑战及控制与消除策略》
Infect Dis Rep. 2016 Jun 24;8(2):6570. doi: 10.4081/idr.2016.6570.
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Diagnosis and management of miliary tuberculosis: current state and future perspectives.粟粒性肺结核的诊断与治疗:现状与未来展望。
Stance of pathology residents on declining number of autopsies.
病理学住院医师对尸检数量下降的态度。
Autops Case Rep. 2018 Feb 27;8(1):e2018007. doi: 10.4322/acr.2018.007. eCollection 2018 Jan-Mar.
Ther Clin Risk Manag. 2013;9:9-26. doi: 10.2147/TCRM.S29179. Epub 2013 Jan 8.
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An autopsy study describing causes of death and comparing clinico-pathological findings among hospitalized patients in Kampala, Uganda.一项描述乌干达坎帕拉住院患者死因并比较临床病理发现的尸检研究。
PLoS One. 2012;7(3):e33685. doi: 10.1371/journal.pone.0033685. Epub 2012 Mar 14.
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Acute generalized miliary tuberculosis in adults.成人急性全身性粟粒性肺结核
N Engl J Med. 1946 Aug 22;235:239-48. doi: 10.1056/nejm194608222350801.
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Discrepancies between clinical diagnoses and autopsy findings.临床诊断与尸检结果之间的差异。
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Pathology and causes of death in a group of 128 predominantly HIV-positive patients in Botswana, 1997-1998.1997 - 1998年博茨瓦纳一组主要为艾滋病毒阳性的128名患者的病理学及死因
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