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犬尿喹啉酸和AP5可区分NMDA受体激动剂。

Kynurenic acid and AP5 distinguish between NMDA receptor agonists.

作者信息

Williams T L, Stone T W, Burton N R, Smith D A

机构信息

Department of Physiology, St. George's Hospital Medical School, London, United Kingdom.

出版信息

Exp Neurol. 1988 Dec;102(3):366-7. doi: 10.1016/0014-4886(88)90232-4.

DOI:10.1016/0014-4886(88)90232-4
PMID:2904376
Abstract

Quantitative analysis of responses to amino acids in mouse cortical slices has indicated that the antagonists kynurenate and 2-amino-5-phosphonopentanoic acid distinguish between ibotenate and both N-methyl-D-aspartate (NMDA) and quinolinate. This result is consistent with the existence of NMDA-receptor subtypes.

摘要

对小鼠皮质切片中氨基酸反应的定量分析表明,拮抗剂犬尿烯酸和2-氨基-5-磷酸戊酸可区分鹅膏蕈氨酸与N-甲基-D-天冬氨酸(NMDA)及喹啉酸。该结果与NMDA受体亚型的存在相一致。

相似文献

1
Kynurenic acid and AP5 distinguish between NMDA receptor agonists.犬尿喹啉酸和AP5可区分NMDA受体激动剂。
Exp Neurol. 1988 Dec;102(3):366-7. doi: 10.1016/0014-4886(88)90232-4.
2
A quantitative pharmacological analysis of some excitatory amino acid receptors in the mouse neocortex in vitro.小鼠新皮质中某些兴奋性氨基酸受体的体外定量药理学分析。
Br J Pharmacol. 1988 Mar;93(3):693-701. doi: 10.1111/j.1476-5381.1988.tb10328.x.
3
Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.犬尿喹啉酸和喹啉酸作用于大鼠海马体中的N-甲基-D-天冬氨酸受体。
J Pharmacol Exp Ther. 1986 Jan;236(1):293-9.
4
Amino acid pharmacology in neocortical slices: evidence for bimolecular actions from an extension of the Hill and Gaddum-Schild equations.新皮质切片中的氨基酸药理学:基于希尔方程和加德姆-席尔德方程扩展的双分子作用证据。
Br J Pharmacol. 1988 Nov;95(3):805-10. doi: 10.1111/j.1476-5381.1988.tb11708.x.
5
Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique.利用波动分析和快速灌注技术研究N-甲基-D-天冬氨酸受体拮抗剂作用位点。
J Neurophysiol. 1988 Aug;60(2):645-63. doi: 10.1152/jn.1988.60.2.645.
6
A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat.大鼠中由海藻酸、喹啉酸、鹅膏蕈氨酸、N-甲基-D-天冬氨酸或使君子氨酸引起的基底前脑兴奋毒性损伤的比较,以及2-氨基-5-磷酸戊酸和犬尿烯酸对毒性的影响。
Br J Pharmacol. 1991 Apr;102(4):904-8. doi: 10.1111/j.1476-5381.1991.tb12274.x.
7
Suppression of ictal-like activity by kynurenic acid does not correlate with its efficacy as an NMDA receptor antagonist.
Epilepsy Res. 1988 Jul-Aug;2(4):232-8. doi: 10.1016/0920-1211(88)90013-7.
8
Ca2+-dependent depolarization and burst firing of rat CA1 pyramidal neurones induced by N-methyl-D-aspartic acid and quinolinic acid: antagonism by 2-amino-5-phosphonovaleric and kynurenic acids.N-甲基-D-天冬氨酸和喹啉酸诱导的大鼠CA1锥体神经元的钙依赖性去极化和爆发式放电:2-氨基-5-磷酸戊酸和犬尿烯酸的拮抗作用
Can J Physiol Pharmacol. 1986 Feb;64(2):163-8. doi: 10.1139/y86-024.
9
The relative potencies of (-)-2-amino-5-phosphonovalerate and (-)-2-amino-7-phosphonoheptanoate as antagonists of N-methylaspartate and quinolinic acids and repetitive spikes in rat hippocampal slices.(-)-2-氨基-5-磷酸戊酸和(-)-2-氨基-7-磷酸庚酸作为N-甲基-D-天冬氨酸和喹啉酸拮抗剂以及对大鼠海马切片中重复放电的相对效能。
Brain Res. 1986 Aug 27;381(1):195-8. doi: 10.1016/0006-8993(86)90713-4.
10
A comparison of the effects of N-methyl-D-aspartate and quinolinate on central neurones of the rat.N-甲基-D-天冬氨酸与喹啉酸对大鼠中枢神经元作用的比较。
Neurosci Lett. 1984 May 4;46(2):157-60. doi: 10.1016/0304-3940(84)90434-8.

引用本文的文献

1
Neurochemical and behavioural investigations of the NMDA receptor-associated glycine site in the rat striatum: functional implications for treatment of parkinsonian symptoms.大鼠纹状体中N-甲基-D-天冬氨酸(NMDA)受体相关甘氨酸位点的神经化学与行为学研究:对帕金森氏症症状治疗的功能意义
Psychopharmacology (Berl). 1995 May;119(1):55-65. doi: 10.1007/BF02246054.
2
A review of the in vitro and in vivo neurochemical characterization of the NMDA/PCP/glycine/ion channel receptor macrocomplex.N-甲基-D-天冬氨酸/苯环己哌啶/甘氨酸/离子通道受体大复合物的体外和体内神经化学特征综述。
Neurochem Res. 1990 Feb;15(2):217-30. doi: 10.1007/BF00972212.
3
Two types of steady-state desensitization of N-methyl-D-aspartate receptor in isolated hippocampal neurones of rat.
大鼠离体海马神经元中N-甲基-D-天冬氨酸受体的两种稳态脱敏类型。
J Physiol. 1992 Mar;448:453-72. doi: 10.1113/jphysiol.1992.sp019051.