新皮质切片中的氨基酸药理学：基于希尔方程和加德姆-席尔德方程扩展的双分子作用证据。
Amino acid pharmacology in neocortical slices: evidence for bimolecular actions from an extension of the Hill and Gaddum-Schild equations.
作者信息
Williams T L, Smith D A, Burton N R, Stone T W
机构信息
Dept. of Physiology, St. George's Hospital Medical School, University of London.
出版信息
Br J Pharmacol. 1988 Nov;95(3):805-10. doi: 10.1111/j.1476-5381.1988.tb11708.x.
Abstract
- The equivalent circuit of the cortical slice preparation has been analysed to show that the measured d.c. voltages can be used to estimate the Hill coefficient for ligands acting on the pyramidal cell bodies. 2. The Gaddum-Schild equation for agonist-antagonist interactions has been modified for applications in which the Hill coefficient is not equal to 1. 3. The equations obtained have been applied to recent data of Burton et al. (1988). The results provide evidence for a bimolecular action of the agonists N-methyl-D-aspartate (NMDA) and quinolinic acid and the antagonists kynurenic acid and 2-amino-5-phosphono-pentanoic acid at NMDA receptors on mouse neocortical pyramidal cells.
摘要
- 对皮质切片标本的等效电路进行了分析，结果表明所测得的直流电压可用于估算作用于锥体细胞体的配体的希尔系数。2. 针对希尔系数不等于1的应用情况，对激动剂 - 拮抗剂相互作用的加德姆 - 席尔德方程进行了修正。3. 所得方程已应用于伯顿等人（1988年）的最新数据。结果为激动剂N - 甲基 - D - 天冬氨酸（NMDA）和喹啉酸以及拮抗剂犬尿烯酸和2 - 氨基 - 5 - 磷酸戊酸在小鼠新皮质锥体细胞NMDA受体上的双分子作用提供了证据。
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Amino acid pharmacology in neocortical slices: evidence for bimolecular actions from an extension of the Hill and Gaddum-Schild equations.新皮质切片中的氨基酸药理学：基于希尔方程和加德姆-席尔德方程扩展的双分子作用证据。
Br J Pharmacol. 1988 Nov;95(3):805-10. doi: 10.1111/j.1476-5381.1988.tb11708.x.
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