Yang Yifan, Fang Jugao, Zhong Qi, Xu Wen, Ma Hongzhi, Feng Ling, Shi Qian, Lian Meng, Wang Ru, Hou Lizhen
a Department of Otorhinolaryngology Head and Neck Surgery , Beijing Tongren Hospital, Capital Medical University , Beijing , China.
b Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education , Beijing Institute of Otorhinolaryngology , Beijing , China.
Acta Otolaryngol. 2018 Apr;138(4):400-406. doi: 10.1080/00016489.2017.1388542. Epub 2017 Oct 18.
Narrow band imaging (NBI) and stroboscopy are non-invasive techniques to detect the malignant lesions of the vocal cord. This study was to assess the diagnostic value of combined endoscopic analysis in the applanate indiscernible early-stage vocal cord cancer.
A total of 110 patients with 160 suspicious vocal cord malignant lesions were included in this retrospective study. Stroboscopy was immediately performed after NBI and white light endoscopy (WLE) were performed in all patients. Excisional biopsy was performed to examine histopathology examination.
We found that the diagnostic specificity and PPV were higher in the NBI and WLE combined with stroboscopy group than in the NBI and WLE group without stroboscopy (88.9% vs 72.5%, 88.4% vs 60.9%). However, the diagnostic sensitivity was not significantly different in those two groups (69.3% vs 67.7%).
NBI and WLE combined with stroboscopy is a promising method to detect early-stage vocal cord cancer with the advantage of clinical feasibility and diagnostic specificity.
窄带成像（NBI）和频闪喉镜检查是检测声带恶性病变的非侵入性技术。本研究旨在评估联合内镜分析在扁平不可辨别的早期声带癌中的诊断价值。
本回顾性研究共纳入110例患者，其声带存在160处可疑恶性病变。所有患者均先进行NBI和白光内镜检查（WLE），随后立即进行频闪喉镜检查。进行切除活检以检查组织病理学。
我们发现，NBI和WLE联合频闪喉镜检查组的诊断特异性和阳性预测值高于未进行频闪喉镜检查的NBI和WLE组（88.9%对72.5%，88.4%对60.9%）。然而，两组的诊断敏感性无显著差异（69.3%对67.7%）。
NBI和WLE联合频闪喉镜检查是一种有前景的检测早期声带癌的方法，具有临床可行性和诊断特异性的优势。
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