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[硫磺阴道灌洗与外阴阴道萎缩]

[Sulphurous vaginal douching and vulvovaginal atrophy].

作者信息

Costantino M, Conti V, Marongiu M B, Napolano G, Filippelli A

机构信息

Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana", Università degli Studi di Salerno, Italia - Associazione non profit F.I.R.S.Thermae (Formazione Interdisciplinare, Ricerche e Scienze Termali) in Anagrafe Nazionale di Ricerche del MiUR.

Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana", Università degli Studi di Salerno, Italia.

出版信息

Clin Ter. 2017 Sep-Oct;168(5):e300-e306. doi: 10.7417/T.2017.2025.

Abstract

OBJECTIVE

During climacteric the reduction or interruption of estrogenic stimulus determines a gradual atrophy of the tissues of the urogenital tract.Vulvovaginal atrophy can be cause of dryness, itch, burning, and dyspareunia. Vulvovaginal atrophy is associated also with depression. Hence the importance of an appropriate treatment of the vulvovaginal atrophy. Between therapeutic options we can add, particularly for women who suffer only from vaginal symptoms, the spa therapy that uses mineral waters with benefic effects on vaginal tissue wellness and health. On the basis of considerations described above and on the insufficient literature data, the objective of our single-arm pilot study has been to evaluate, in women suffering from vulvovaginal atrophy, the effects and safety of a vaginal douching cycle with sulphurous mineral water and impact on depression disorder frequently observed.

PATIENTS AND METHODS

The study was conducted on 24 women affected by vulvovaginal atrophy; mean age:57±11 years; age range:42-81 years. The subjects were treated, for 2 weeks, with sulphurous vaginal douching from Terme of Telese S.p.A. (Benevento-Italy). At the beginning and at the end of the SPA treatment the following symptoms were evaluated: dryness, burning, itch, dyspareunia and leucorrhoea (using VAS scale); the impact on psychological distress (using S.D.S. Zung-test).

RESULT

At the end of the spa treatment, the mean values±SD, compared to baseline, have showed a significant (p<0.05) reduction in leucorrhoea (-88%), in vulvar itch (-79%), in vaginal burning (-71%), in vaginal dryness (-65%) with an improvement of psichological distress as demonstrated by S.D.S. Zung-test.

CONCLUSION

The data of this single-arm pilot clinical trial show that the sulphurous vaginal douching cycle can be considered very useful in women suffering from vulvovaginal atrophy with improving of the quality of life and social relationship.

摘要

目的

在更年期期间,雌激素刺激的减少或中断会导致泌尿生殖道组织逐渐萎缩。外阴阴道萎缩可能导致干燥、瘙痒、灼痛和性交困难。外阴阴道萎缩还与抑郁有关。因此,适当治疗外阴阴道萎缩非常重要。在治疗选择中,我们可以增加,特别是对于仅患有阴道症状的女性,使用对阴道组织健康有益的矿泉水的水疗疗法。基于上述考虑以及文献数据不足,我们单臂试点研究的目的是评估患有外阴阴道萎缩的女性使用含硫矿泉水进行阴道灌洗周期的效果和安全性,以及对常见抑郁症的影响。

患者与方法

该研究对24名患有外阴阴道萎缩的女性进行;平均年龄:57±11岁;年龄范围:42 - 81岁。受试者接受了来自意大利贝内文托的泰莱斯温泉公司(Terme of Telese S.p.A.)的含硫阴道灌洗,为期2周。在水疗治疗开始和结束时,评估以下症状:干燥、灼痛、瘙痒、性交困难和白带(使用视觉模拟量表);对心理困扰的影响(使用Zung氏抑郁自评量表)。

结果

水疗治疗结束时,与基线相比,平均值±标准差显示白带(-88%)、外阴瘙痒(-79%)、阴道灼痛(-71%)、阴道干燥(-65%)有显著(p<0.05)降低,并且Zung氏抑郁自评量表显示心理困扰有所改善。

结论

这项单臂试点临床试验的数据表明,含硫阴道灌洗周期对患有外阴阴道萎缩的女性非常有用,可改善生活质量和社会关系。

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