Wang Qi, Ge Xing, Wang Heng-Xue, Shi Qiao-Mei, Ding Zhen, Xu Li-Chun
School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Andrologia. 2018 Apr;50(3). doi: 10.1111/and.12909. Epub 2017 Oct 18.
Researches on association between variations in the androgen receptor (AR) gene repeat polymorphisms and cryptorchidism (CO) had conflicting results. The aim of this meta-analysis was to analyse the potential effects of AR CAG and/or GGN repeat polymorphism on CO. Studies were independently appraised by two investigators on PubMed, Web of Science, EBSCO databases and Foreign Medical Retrieval System. Case-control studies with measurement of CAG and/or GGN repeat length were included. Weighted mean difference (WMD) and 95% confidence intervals (CIs) for the CAG or GGN repeat polymorphism and CO were calculated. Five reports were included in this analysis. Overall, no difference was identified between patients and fertile men in CAG repeat length. However, when the CO was divided into unilateral and bilateral, longer CAG repeat region was significantly associated with CO in bilateral group (WMD = 0.74; 95% CI, 0.01-1.47; p < .05). In addition, GGN lengths were significantly higher in patients compared with those in controls (WMD = 1.17; 95% CI, 0.28-2.06; p < .05). No obvious effect was found in the GGN length when compared unilateral or bilateral group with control respectively. The results in this meta-analysis indicated that AR CAG and GGN repeat polymorphisms may be an important pathogenesis of CO.
关于雄激素受体（AR）基因重复多态性变异与隐睾症（CO）之间关联的研究结果相互矛盾。本荟萃分析的目的是分析AR CAG和/或GGN重复多态性对CO的潜在影响。两名研究人员分别在PubMed、科学网、EBSCO数据库和国外医学检索系统上独立评估研究。纳入测量CAG和/或GGN重复长度的病例对照研究。计算CAG或GGN重复多态性与CO的加权平均差（WMD）和95%置信区间（CI）。本分析纳入了五篇报告。总体而言，患者与有生育能力男性的CAG重复长度无差异。然而，当将CO分为单侧和双侧时，双侧组中较长的CAG重复区域与CO显著相关（WMD = 0.74；95%CI，0.01 - 1.47；p < 0.05）。此外，患者的GGN长度显著高于对照组（WMD = 1.17；95%CI，0.28 - 2.06；p < 0.05）。分别将单侧或双侧组与对照组比较时，未发现GGN长度有明显影响。本荟萃分析结果表明，AR CAG和GGN重复多态性可能是CO的重要发病机制。
