Wagner Benjamin R, Frishman William H
Cardiol Rev. 2018 Jan/Feb;26(1):43-49. doi: 10.1097/CRD.0000000000000171.
Heart failure (HF) is associated with significant morbidity and mortality and an increasing economic burden. The persistence of HF's risk factors, coupled with an aging population, also leads to an increase in its incidence and prevalence. It is well established that sympathetic hyperactivity and parasympathetic withdrawal are instrumental in the development and worsening of HF. Therefore, restoring autonomic balance to the cardiovascular system is an attractive therapeutic approach. The following is a review of current clinical trials of device-based autonomic regulation therapy in the management of HF with a reduced ejection fraction.
心力衰竭（HF）与显著的发病率、死亡率以及不断增加的经济负担相关。HF危险因素的持续存在，再加上人口老龄化，也导致其发病率和患病率上升。交感神经过度活跃和副交感神经功能减退在HF的发生和恶化中起重要作用，这一点已得到充分证实。因此，恢复心血管系统的自主神经平衡是一种有吸引力的治疗方法。以下是对目前基于设备的自主神经调节疗法治疗射血分数降低的HF的临床试验的综述。
