Tone Alicia A
Division of Gynecologic Oncology, Princess Margaret Cancer Center, Toronto, Ontario, Canada.
Clin Obstet Gynecol. 2017 Dec;60(4):697-710. doi: 10.1097/GRF.0000000000000313.
Detailed pathologic studies over the past decade suggest a distal fallopian tube origin for the majority of "ovarian" high-grade serous carcinomas (HGSC). This review will summarize molecular alterations observed in tubal precursors for HGSC, namely p53 signatures and serous tubal intraepithelial carcinomas, and in nonmalignant fallopian tube epithelial cells obtained from women at increased genetic risk for HGSC. Recent experiments investigating the impact of follicular fluid exposure and retrograde menstruation on tumor development in the fallopian tube will also be discussed. These data will be reconciled with traditional ovarian cancer risk factors related to reproductive history.
过去十年的详细病理学研究表明，大多数“卵巢”高级别浆液性癌（HGSC）起源于输卵管远端。本综述将总结在HGSC的输卵管前体中观察到的分子改变，即p53特征和浆液性输卵管上皮内癌，以及从患HGSC遗传风险增加的女性中获得的非恶性输卵管上皮细胞中的分子改变。还将讨论最近关于卵泡液暴露和逆行月经对输卵管肿瘤发生影响的实验。这些数据将与与生殖史相关的传统卵巢癌风险因素进行整合。
