头孢洛林在耐甲氧西林金黄色葡萄球菌肺炎早产儿中的药代动力学。
Pharmacokinetics of Ceftaroline in a Preterm Infant With Methicillin-Resistant Staphylococcus Aureus Pneumonia.
机构信息
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy.
Department of Pediatrics, The University of North Carolina at Chapel Hill.
出版信息
J Pediatric Infect Dis Soc. 2018 Dec 3;7(4):342-345. doi: 10.1093/jpids/pix084.
Abstract
We report here the first pharmacokinetic-pharmacodynamic relationship for ceftaroline in a preterm infant born at <28 weeks' gestational age who was given ceftaroline (8.5 mg/kg every 8 hours) for pneumonia attributable to methicillin-resistant Staphyloccocus aureus. This dose of ceftaroline was adequate to achieve the pharmacodynamic endpoint associated with efficacy for methicillin-resistant Staphyloccocus aureus.
摘要
我们在此报告首例<28 周胎龄早产儿的头孢洛林药代动力学-药效学关系，该早产儿因耐甲氧西林金黄色葡萄球菌引起的肺炎接受了头孢洛林（8.5 毫克/千克，每 8 小时一次）治疗。该剂量的头孢洛林足以达到与耐甲氧西林金黄色葡萄球菌疗效相关的药效学终点。
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