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Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease.
JCI Insight. 2017 Oct 19;2(20):95085. doi: 10.1172/jci.insight.95085.
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Impact of maternal hyperglycemia on cardiac development: Insights from animal models.
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3
Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes.
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Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.
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Maternal hyperglycemia and fetal cardiac development: Clinical impact and underlying mechanisms.
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Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 expression via histone modification in the developing heart.
J Biol Chem. 2012 Jan 6;287(2):1235-41. doi: 10.1074/jbc.M111.315945. Epub 2011 Nov 21.
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Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes.
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Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression.
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Genetics of Congenital Heart Disease: A Narrative Review of Challenges and Strategies in Identifying Novel Genes.
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Epigenetic Mechanisms in Heart Diseases.
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Macromolecular interactions dictate Polycomb-mediated epigenetic repression.
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Genetic and Environmental Contributors To Congenital Heart Disease.
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The ERBB2 c.1795C>T, p.Arg599Cys variant is associated with left ventricular outflow tract obstruction defects in humans.
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Role of Maternal Obesity in Offspring Cardiovascular Development and Congenital Heart Defects.
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Congenital heart defects and consanguinity: An analysis of the Sidra cardiac registry data in Qatar.
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本文引用的文献

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The complex genetics of hypoplastic left heart syndrome.
Nat Genet. 2017 Jul;49(7):1152-1159. doi: 10.1038/ng.3870. Epub 2017 May 22.
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Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency.
J Clin Invest. 2017 May 1;127(5):1683-1688. doi: 10.1172/JCI90338. Epub 2017 Mar 27.
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KLF2 and KLF4 control endothelial identity and vascular integrity.
JCI Insight. 2017 Feb 23;2(4):e91700. doi: 10.1172/jci.insight.91700.
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Effects of oxidative stress on hyperglycaemia-induced brain malformations in a diabetes mouse model.
Exp Cell Res. 2016 Sep 10;347(1):201-211. doi: 10.1016/j.yexcr.2016.08.002. Epub 2016 Aug 4.
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Prepregnancy Diabetes and Offspring Risk of Congenital Heart Disease: A Nationwide Cohort Study.
Circulation. 2016 Jun 7;133(23):2243-53. doi: 10.1161/CIRCULATIONAHA.115.017465. Epub 2016 May 10.
8
Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract.
J Am Heart Assoc. 2016 Apr 22;5(4):e003075. doi: 10.1161/JAHA.115.003075.
9
De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.
PLoS Genet. 2016 Apr 8;12(4):e1005963. doi: 10.1371/journal.pgen.1005963. eCollection 2016 Apr.
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Genetic and Developmental Basis of Cardiovascular Malformations.
Clin Perinatol. 2016 Mar;43(1):39-53. doi: 10.1016/j.clp.2015.11.002.

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