Sak Mark, Duric Neb, Littrup Peter, Sherman Mark, Gierach Gretchen
Delphinus Medical Technologies, 45525 Grand River, Novi, MI, 48374.
Mayo Clinic, Jacksonville Florida, 32224.
Proc SPIE Int Soc Opt Eng. 2017 Mar;10139. doi: 10.1117/12.2254472.
Ultrasound tomography (UST) is an emerging modality that can offer quantitative measurements of breast density. Recent breakthroughs in UST image reconstruction involve the use of a waveform reconstruction as opposed to a ray-based reconstruction. The sound speed (SS) images that are created using the waveform reconstruction have a much higher image quality. These waveform images offer improved resolution and contrasts between regions of dense and fatty tissues. As part of a study that was designed to assess breast density changes using UST sound speed imaging among women undergoing tamoxifen therapy, UST waveform sound speed images were then reconstructed for a subset of participants. These initial results show that changes to the parenchymal tissue can more clearly be visualized when using the waveform sound speed images. Additional quantitative testing of the waveform images was also started to test the hypothesis that waveform sound speed images are a more robust measure of breast density than ray-based reconstructions. Further analysis is still needed to better understand how tamoxifen affects breast tissue.
超声断层成像（UST）是一种新兴的成像方式，能够对乳腺密度进行定量测量。UST图像重建方面的最新突破涉及使用波形重建而非基于射线的重建。通过波形重建生成的声速（SS）图像具有更高的图像质量。这些波形图像在致密组织和脂肪组织区域之间提供了更高的分辨率和对比度。作为一项旨在利用UST声速成像评估接受他莫昔芬治疗的女性乳腺密度变化的研究的一部分，随后为一部分参与者重建了UST波形声速图像。这些初步结果表明，使用波形声速图像时，实质组织的变化能够更清晰地显现出来。还开始对波形图像进行额外的定量测试，以检验波形声速图像比基于射线的重建更能可靠地测量乳腺密度这一假设。仍需要进一步分析，以更好地了解他莫昔芬如何影响乳腺组织。
