Maillis A, Karayanidis F, Koutsoukos E, Angelopoulos E, Stefanis C
Department of Psychiatry, Athens University, Eginition Hospital, Greece.
Neuropsychobiology. 1988;19(3):139-45. doi: 10.1159/000118449.
Piracetam, when applied microiontophoretically and/or by hydropneumatic pump on the somatosensory cortex and hippocampus of the rat, affected neuronal activity by depressing or facilitating the spontaneous firing rate, depending on the area studied. Its effect were either additive or counteracting the actions of glutamate, gamma-aminobutyric acid and acetylcholine, when administered together on the same neuron, thus supporting the assumption that its action is directed towards specific membrane elements, presumably the synaptic sites.
当将吡拉西坦通过微量离子电泳法和/或通过液压气动泵施加于大鼠的体感皮层和海马体时，根据所研究的区域，它会通过降低或促进自发放电率来影响神经元活动。当与谷氨酸、γ-氨基丁酸和乙酰胆碱一起施用于同一神经元时，其作用要么是相加的，要么是抵消这些物质的作用，因此支持了这样一种假设，即其作用是针对特定的膜成分，大概是突触部位。
