Zhu Liping, Lu Yankai, Zhang Jiwei, Hu Qinghua
Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, People's Republic of China.
Adv Exp Med Biol. 2017;967:385-398. doi: 10.1007/978-3-319-63245-2_25.
Oxidative and antioxidative system of cells and tissues maintains a balanced state under physiological conditions. A disruption in this balance of redox status has been associated with numerous pathological processes. Reactive oxygen species (ROS) as a major redox signaling generates in a spatiotemporally dependent manner. Subcellular organelles such as mitochondria, endoplasmic reticulum, plasma membrane and nuclei contribute to the production of ROS. In addition to downstream effects of ROS signaling regulated by average ROS changes in cytoplasm, whether subcelluar ROS mediate biological effect(s) has drawn greater attentions. With the advance in redox-sensitive probes targeted to different subcellular compartments, the investigation of subcellular ROS signaling and its associated cellular function has become feasible. In this review, we discuss the subcellular ROS signaling, with particular focus on mechanisms of subcellular ROS production and its downstream effects.
细胞和组织的氧化与抗氧化系统在生理条件下维持着平衡状态。这种氧化还原状态平衡的破坏与众多病理过程相关。作为主要氧化还原信号的活性氧（ROS）以时空依赖的方式产生。线粒体、内质网、质膜和细胞核等亚细胞器参与了ROS的产生。除了细胞质中ROS平均变化所调节的ROS信号下游效应外，亚细胞ROS是否介导生物学效应已引起了更多关注。随着针对不同亚细胞区室的氧化还原敏感探针的发展，对亚细胞ROS信号及其相关细胞功能的研究变得可行。在这篇综述中，我们讨论亚细胞ROS信号，特别关注亚细胞ROS产生的机制及其下游效应。
