Perkins S L, Tattrie B, Johnson P M, Rabin E Z
Division of Biochemistry, Ottawa Civic Hospital, Ontario, Canada.
Ther Drug Monit. 1988;10(4):480-5. doi: 10.1097/00007691-198804000-00019.
Good clinical control of hypertension is achieved with low doses of the potent beta-blocker bopindolol. Pharmacokinetic evaluations therefore require an analytical technique of high sensitivity. Analysis of plasma by high-performance liquid chromatography (HPLC) using electrochemical detection provides this sensitivity. This article describes the development of an analytical procedure and presents a reversed-phase HPLC method with coulometric detection suitable for plasma analyses during pharmacokinetic investigations of bopindolol therapy.
使用低剂量强效β受体阻滞剂波吲洛尔可实现高血压的良好临床控制。因此，药代动力学评估需要一种高灵敏度的分析技术。采用电化学检测的高效液相色谱法（HPLC）分析血浆可提供这种灵敏度。本文描述了一种分析方法的开发，并提出了一种适用于波吲洛尔治疗药代动力学研究期间血浆分析的具有库仑检测的反相HPLC方法。
