Stingl G
Abteilung für Immunbiologie der Haut, I. Universitäts-Hautklinik Wien.
Wien Med Wochenschr. 1988 Oct 31;138(19-20):487-92.
Although, in the course of HIV-1-infection, the functional capacities of virtually all immune cells are greatly impaired, only CD4+ cells (antigen-presenting cells, helper T cells) are directly infected by the virus. CD4+ T cells are involved, to a greater or lesser degree, in the induction of virtually all immunologic phenomena, either directly or indirectly. Thus, it is clear that the HIV-1-induced depletion and functional impairment of this critical T cell subset will result in a dysfunction/deficiency of the entire immune system and, finally, in the development of opportunistic infections and neoplasms.
虽然在HIV-1感染过程中，几乎所有免疫细胞的功能能力都受到极大损害，但只有CD4+细胞（抗原呈递细胞、辅助性T细胞）会被该病毒直接感染。CD4+ T细胞或多或少地直接或间接参与几乎所有免疫现象的诱导。因此，很明显，HIV-1诱导的这一关键T细胞亚群的耗竭和功能损害将导致整个免疫系统功能失调/缺陷，最终导致机会性感染和肿瘤的发生。
