促癌佛波酯对大鼠前列腺上皮细胞中环磷酸腺苷积累的β-肾上腺素能激动剂刺激的抑制作用。

Inhibitory action of tumor-promoting phorbol esters upon beta-adrenergic agonist stimulation of cyclic AMP accumulation in rat prostatic epithelial cells.

作者信息

Carmena M J, Escudero F, Prieto J C

机构信息

Departamento de Bioquímica y Biología Molecular, Universidad de Alcala, Madrid, Spain.

出版信息

Biochem Int. 1988 Sep;17(3):427-32.

Abstract

The pretreatment of rat prostatic epithelial cells with 4 beta-phorbol 12-myristate 13-acetate resulted in an attenuation of beta-adrenergic stimulated cyclic AMP accumulation. The effect was dependent on time and concentration. The maximal extent of isoproterenol stimulation of cyclic AMP production was reduced by 35% after 15-min pretreatment with the phorbol ester at 25 degrees C. Since a similar action was exerted by other protein kinase C stimulators, present results suggest the involvement of this enzyme in a process of desensitization to beta-adrenergic agonists of the adenylate cyclase system in rat prostatic epithelium.

摘要

用4β-佛波醇12-肉豆蔻酸酯13-乙酸酯预处理大鼠前列腺上皮细胞，导致β-肾上腺素能刺激的环磷酸腺苷（cAMP）积累减弱。该效应取决于时间和浓度。在25℃下用佛波醇酯预处理15分钟后，异丙肾上腺素对cAMP产生的最大刺激程度降低了35%。由于其他蛋白激酶C刺激剂也有类似作用，目前的结果表明该酶参与了大鼠前列腺上皮中腺苷酸环化酶系统对β-肾上腺素能激动剂脱敏的过程。

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