口服抗组胺药阿司咪唑对组胺诱导的结膜炎的阻断作用。

Blocking of histamine-induced conjunctivitis by the oral antihistamine, astemizole.

作者信息

Stokes T C, Feinberg G

机构信息

Chest Department, United Medical School, St Thomas' Campus, London.

出版信息

Br J Clin Pharmacol. 1988 Jun;25(6):771-3. doi: 10.1111/j.1365-2125.1988.tb05267.x.

DOI:10.1111/j.1365-2125.1988.tb05267.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1386458/

Abstract

When histamine is applied topically to the eye it produces stinging and inflammation of the caruncle and bulbar and palpebral conjunctiva. This model has been employed in the present study to assess the ability of an oral antihistamine, astemizole, to attenuate the irritation and inflammatory signs. Astemizole 30 mg, taken orally once daily for 1 week, considerably lessened the stinging and significantly lowered the signs of inflammation caused by topically applied histamines.

摘要

当将组胺局部应用于眼部时，会引起泪阜、球结膜和睑结膜的刺痛及炎症。本研究采用该模型来评估口服抗组胺药阿司咪唑减轻刺激和炎症体征的能力。每日口服一次30毫克阿司咪唑，持续1周，可显著减轻局部应用组胺引起的刺痛，并明显降低炎症体征。

相似文献

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本文引用的文献

1

The development of tolerance to antihistamines; a study of the quantitative inhibiting capacity of antihistamines on the skin and mucous membrane reaction to histamine and antigens.抗组胺药耐受性的发展；抗组胺药对皮肤和黏膜对组胺及抗原反应的定量抑制能力的研究。

J Allergy. 1951 Jul;22(4):330-9. doi: 10.1016/0021-8707(51)90033-0.

2

Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever.两种非镇静性H1抗组胺药（特非那定和阿司咪唑）治疗花粉热的对比试验。

Thorax. 1984 Sep;39(9):668-72. doi: 10.1136/thx.39.9.668.

3

Leucocyte infiltration into the conjunctiva following topical challenge with antigen, histamine, or compound 48/80.在用抗原、组胺或48/80化合物进行局部刺激后，白细胞浸润结膜。

Monogr Allergy. 1977;12:213-5.

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