糖皮质激素和儿茶酚胺对成熟大鼠心脏的影响。

Effects of glucocorticoids and catecholamines on maturing rat heart.

Penefsky Z J

Department of Physiology and Biophysics, Mount Sinai School of Medicine of the City University of New York 10029.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;90(1):133-44. doi: 10.1016/0742-8413(88)90109-0.

Abstract

The negative force-frequency response of normal rat heart was accentuated when the animals were adrenalectomized. Treatment of adrenalectomized animals with dexamethasone restored the normal force-frequency response. 2. Total adrenalectomy increased the sensitivity of rat heart to calcium. 3. Adrenalectomized-dexamethasone-treated hearts were more responsive to epinephrine and ouabain. 4. Total adrenalectomy caused independent myocardial disturbances in calcium handling elements (glucocorticoid effect) and beta receptors (catecholamine effect).

摘要

当大鼠进行肾上腺切除术后，正常大鼠心脏的负性力-频率反应会增强。用地塞米松治疗肾上腺切除的动物可恢复正常的力-频率反应。2. 全肾上腺切除术增加了大鼠心脏对钙的敏感性。3. 经肾上腺切除-地塞米松治疗的心脏对肾上腺素和哇巴因更敏感。4. 全肾上腺切除术在钙处理元件（糖皮质激素效应）和β受体（儿茶酚胺效应）方面引起了独立的心肌紊乱。