三种氯苯氧基乙酸（2,4-二氯苯氧乙酸、2,4,5-三氯苯氧乙酸和灭草灵）对脑血管损伤的比较研究

Comparative study on cerebrovascular injuries by three chlorophenoxyacetic acids (2,4-D, 2,4,5-T and MCPA).

作者信息

Elo H A, Hervonen H, Ylitalo P

机构信息

Department of Pharmacology and Toxicology, University of Kuopio, Finland.

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;90(1):65-8. doi: 10.1016/0742-8413(88)90098-9.

DOI:10.1016/0742-8413(88)90098-9

PMID:2904874

Abstract

At toxic doses in rats, 2,4-dichlorophenoxyacetic acid (2,4-D) and 2-methyl-4-chlorophenoxyacetic acid (MCPA) caused injuries in blood vessels in the brain. 2. 2,4-D caused extravasations of the circulating Evans blue-albumin complex also in the spinal cord. 3. By contrast, potency in damaging cerebral vessels was almost non-existent with 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). 4. None of the three chlorophenoxyacetic acids caused such cerebrovascular injuries in mice, guinea pigs, Syrian hamsters, rabbits and chickens.

摘要

在大鼠的中毒剂量下，2,4-二氯苯氧乙酸（2,4-D）和2-甲基-4-氯苯氧乙酸（MCPA）会导致脑部血管损伤。2. 2,4-D还会导致脊髓中循环的伊文思蓝-白蛋白复合物外渗。3. 相比之下，2,4,5-三氯苯氧乙酸（2,4,5-T）几乎不存在损伤脑血管的作用。4. 这三种氯苯氧乙酸在小鼠、豚鼠、叙利亚仓鼠、兔子和鸡中均未引起此类脑血管损伤。