Shen Chih-Jung, Kao Chia-Hung, Hsu Tai-Yi, Chen Chih-Yu, Lin Cheng-Li, Shih Hong-Mo
Department of Emergency Medicine School of Medicine, College of Medicine Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine Department of Nuclear Medicine and PET Center Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan Management Office for Health Data Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan, Republic of China.
Medicine (Baltimore). 2017 Oct;96(42):e8041. doi: 10.1097/MD.0000000000008041.
This study investigated whether alcohol intoxication (AI) increases the risk of venous thromboembolism (VTE) by using the Taiwan National Health Insurance Research Database (NHIRD).Using data from the NHIRD, we assembled 61,229 patients with acute AI and randomly selected 244,916 controls. Each patient was monitored from 2000 to 2011 to identify those who were subsequently diagnosed with deep vein thrombosis (DVT) and pulmonary embolism (PE). Cox proportional hazard regression analysis was conducted to determine the risk of VTE in the patients with AI compared with the controls.The incidence rate of DVT during the 10 years follow-up period was 9.36 per 10,000 person-years and 2.07 per 10,000 person-years in the AI and non-AI cohorts, respectively. Moreover, the incidence rate of PE was 4 per 10,000 person-years in the AI cohort and 0.93 in the non-AI cohort. After adjustment for age, sex, and comorbidities, the risks of DVT and PE were 3.40 [95% confidence interval (CI) = 2.83-4.08] and 3.53 (95% CI = 2.69-4.65)-fold higher in the AI cohort than in the non-AI cohort.An increased incidence of VTE was observed among patients with AI. Therefore, physicians should carefully estimate the risk of VTE in patients with AI.
本研究利用台湾全民健康保险研究数据库（NHIRD），调查酒精中毒（AI）是否会增加静脉血栓栓塞症（VTE）的风险。利用NHIRD的数据，我们收集了61229例急性AI患者，并随机选取了244916例对照。对每位患者从2000年至2011年进行监测，以确定那些随后被诊断为深静脉血栓形成（DVT）和肺栓塞（PE）的患者。进行Cox比例风险回归分析，以确定AI患者与对照相比发生VTE的风险。在10年随访期内，AI队列和非AI队列中DVT的发病率分别为每10000人年9.36例和每10000人年2.07例。此外，AI队列中PE的发病率为每10000人年4例，非AI队列中为0.93例。在对年龄、性别和合并症进行调整后，AI队列中DVT和PE的风险分别比非AI队列高3.40倍[95%置信区间（CI）=2.83 - 4.08]和3.53倍（95%CI = 2.69 - 4.65）。在AI患者中观察到VTE发病率增加。因此，医生应仔细评估AI患者发生VTE的风险。
