InSTAR Program, The Schizophrenia Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India; Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, India.
University of Sussex, Brighton, United Kingdom.
Psychiatry Res. 2018 Jan;259:154-159. doi: 10.1016/j.psychres.2017.10.011. Epub 2017 Oct 4.
Some aspects of saccadic performance have been found to be abnormal in chronic schizophrenia. The majority of this research has, however, been performed on patients treated with long-term antipsychotic medication. Very few studies have examined saccadic performance in antipsychotic-naïve/free patients. There are also very few studies describing the relationship between saccadic performance and clinical symptoms, particularly in antipsychotic free patients. In this study, we compared pro and antisaccade performance in a large sample of antipsychotic-naïve/free schizophrenia patients (N = 45) with healthy controls (N = 57). Clinical symptoms were assessed using Scale for Assessment of Positive Symptoms (SAPS) and Negative Symptoms (SANS). In the antisaccade task, patients made significantly more errors, and their correct antisaccades had smaller amplitudes in comparison to healthy controls. Higher error rates were associated with increased severity of hallucinations. In the prosaccade task, patients had less accurate final eye positions, and made saccades with slower latency and reduced amplitude compared to the healthy controls. These observations in schizophrenia patients without the potential confounds of antipsychotic treatment suggest intrinsic link between saccadic deficits and schizophrenia pathogenesis. The relationship between antisaccade errors and hallucination severity supports the potential link between hallucinations and deficits in inhibitory control.
一些眼跳表现的方面在慢性精神分裂症中被发现是异常的。然而，大多数这类研究都是针对长期接受抗精神病药物治疗的患者进行的。几乎没有研究检查过未使用/停用抗精神病药物的患者的眼跳表现。描述眼跳表现与临床症状之间的关系的研究也很少，特别是在未使用/停用抗精神病药物的患者中。在这项研究中，我们比较了大量未经治疗/未使用抗精神病药物的精神分裂症患者（N = 45）和健康对照组（N = 57）的正/反眼跳表现。使用阳性症状评定量表（SAPS）和阴性症状评定量表（SANS）评估临床症状。在反眼跳任务中，与健康对照组相比，患者的错误明显更多，正确的反眼跳幅度更小。更高的错误率与幻觉严重程度增加有关。在正眼跳任务中，与健康对照组相比，患者的最终眼位准确性较低，眼跳潜伏期较慢，幅度较小。这些在未经抗精神病药物治疗潜在混杂因素影响的精神分裂症患者中的观察结果表明，眼跳缺陷与精神分裂症发病机制之间存在内在联系。反眼跳错误与幻觉严重程度之间的关系支持了幻觉与抑制控制缺陷之间的潜在联系。
