Furst D E
Anti-Inflammatory Clinical Research, Ciba-Geigy Pharmaceuticals, Summit, NJ 07901.
J Rheumatol Suppl. 1988 Oct;17:58-62.
While many interactions between nonsteroidal antiinflammatory drugs (NSAID) and other drugs are reported, only a limited number of them are clinically important. These interactions can be divided into those explainable on mainly pharmacokinetic grounds, those explainable on interactions between pharmacokinetics and pharmacodynamics, and those that remain unexplained. Among those explainable on primarily kinetic grounds are interactions of NSAID with antacids, anticoagulants, hypoglycemics, methotrexate, lithium, probenecid, and phenytoin. More complex interactions between dynamics and kinetics are those relating NSAID interactions with diuretics, beta-blockers, other NSAID, and some anticoagulants. Finally important interactions whose causes are not understood include those between aspirin and corticosteroid, indomethacin and triamterene, and flurbiprofen with certain anticoagulants.
虽然有许多关于非甾体抗炎药（NSAID）与其他药物相互作用的报道，但其中只有少数在临床上具有重要意义。这些相互作用可分为主要基于药代动力学原理可解释的相互作用、基于药代动力学与药效学之间相互作用可解释的相互作用以及那些仍无法解释的相互作用。在主要基于动力学原理可解释的相互作用中，有NSAID与抗酸剂、抗凝剂、降糖药、甲氨蝶呤、锂、丙磺舒和苯妥英的相互作用。动力学与药效学之间更复杂的相互作用是那些与NSAID和利尿剂、β受体阻滞剂、其他NSAID以及某些抗凝剂相关的相互作用。最后，原因不明的重要相互作用包括阿司匹林与皮质类固醇之间的相互作用、吲哚美辛与氨苯蝶啶之间的相互作用以及氟比洛芬与某些抗凝剂之间的相互作用。
