Zhai K L, Zhuo G, Chi H B, Lan Z
Medical College of Tibet University, Lhasa 850000, China.
Zhonghua Yi Xue Za Zhi. 2017 Oct 10;97(37):2928-2931. doi: 10.3760/cma.j.issn.0376-2491.2017.37.011.
By the preliminary comparison study on the constituent ratio and clinical characteristics of polycystic ovary syndrome (PCOS) in Tibetan and Han women in Tibetan Plateau, we aimed to find the relevance of its pathogenic factors, and to guide the treatment of PCOS in the plateau region and improve the prognosis. The general situation and clinical data of 165 patients who were diagnosed with PCOS from December 1, 2015 to November 30, 2016 in the Department of Obstetrics and Gynecology of the People's Hospital of Tibet Autonomous Region were analyzed retrospectively. The prevalence of PCOS among Tibetan and Han women in Tibetan Plateau were compared. (1) A total of 1 520 patients were treated in the Tibet Autonomous Region People's Hospital gynecological endocrinology clinics in one year (Tibetan 865 cases, Han 617 cases, other ethnic groups 38 cases), of which patients with PCOS accounted for 10.9% (165/1520). (2) The incidence of Tibetan PCOS patients with oligomenorrhea, infertility, amenorrhea, acne, hairy, LH/FSH inverted, overweight (BMI≥24), and waist circumference >80 cm were 21.2% (35/165), 20.6% (34/165), 16.4% (27/165), 28.5% (47/165), 17% (28/165), 38.2% (63/165), 23.6% (39/165), and 36.4% (60/165), respectively. The incidence of Han PCOS patients with oligomenorrhea, infertility, amenorrhea, acne, hairy, LH/FSH inverted, overweight (BMI≥24), and waist circumference >80 cm were 7.9% (13/165), 10.3% (17/165), 9.1% (15/165), 15.2% (25/165), 9.7% (16/165), 14.5% (24/165), 10.9% (18/165) and 19.4% (32/165), respectively. The proportion of high testosterone in Tibetan PCOS patients was higher than that in Han PCOS patients with statistically significant. (3) The chief complaint of Tibetan PCOS patients were oligomenorrhea and infertility, and the chief complaint of Han PCOS patients were infertility and amenorrhea. (4) The constituent ratio of outpatient clinics in Nyingchi who were with PCOS at an average elevation of about 3 000 meters in the Tibetan Plateau was 7.9% (13/165), and the average constituent ratio in Lhasa, Xigatse and Nagqu over 3 500 meters above sea level was 35.8% (59/165), 16.9% (28/165) and 15.8% (26/165), respectively. The prevalence of PCOS in Tibetan areas is slightly higher than that in the international community. The clinical manifestations of Tibetan patients with PCOS are significantly different from those of Han patients with PCOS. The higher the altitude, the higher the incidence of PCOS.
通过对青藏高原藏族和汉族女性多囊卵巢综合征（PCOS）的构成比及临床特征进行初步对比研究，旨在探寻其致病因素的相关性，以指导高原地区PCOS的治疗并改善预后。回顾性分析2015年12月1日至2016年11月30日在西藏自治区人民医院妇产科确诊为PCOS的165例患者的一般情况及临床资料，比较青藏高原藏族和汉族女性PCOS的患病率。（1）西藏自治区人民医院妇科内分泌门诊一年共诊治1520例患者（藏族865例，汉族617例，其他民族38例），其中PCOS患者占10.9%（165/1520）。（2）藏族PCOS患者中月经稀发、不孕、闭经、痤疮、多毛、LH/FSH倒置、超重（BMI≥24）及腰围>80 cm的发生率分别为21.2%（35/165）、20.6%（34/165）、16.4%（27/165）、28.5%（47/165）、17%（28/165）、38.2%（63/165）、23.6%（39/165）及36.4%（60/165）。汉族PCOS患者中月经稀发、不孕、闭经、痤疮、多毛、LH/FSH倒置、超重（BMI≥24）及腰围>80 cm的发生率分别为7.9%（13/165）、10.3%（17/165）、9.1%（15/165）、15.2%（25/165）、9.7%（16/165）、14.5%（24/165）、10.9%（18/165）及19.4%（32/165）。藏族PCOS患者高睾酮比例高于汉族PCOS患者，差异有统计学意义。（3）藏族PCOS患者主要症状为月经稀发和不孕，汉族PCOS患者主要症状为不孕和闭经。（4）青藏高原平均海拔约3000米的林芝门诊PCOS患者构成比为7.9%（13/165），海拔3500米以上的拉萨、日喀则和那曲门诊PCOS患者平均构成比分别为35.8%（59/165）、16.9%（28/165）及15.8%（26/165）。藏族地区PCOS患病率略高于国际水平。藏族PCOS患者临床表现与汉族PCOS患者明显不同。海拔越高，PCOS发病率越高。
