Sun He-Fen, Zhao Yang, Gao Shui-Ping, Li Liang-Dong, Fu Wen-Yan, Jiang Hong-Lin, Chen Meng-Ting, Yang Li-Peng, Jin Wei
Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Collaborative Innovation Center of Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200030, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200030, China.
Oncotarget. 2017 May 26;8(41):69680-69690. doi: 10.18632/oncotarget.18265. eCollection 2017 Sep 19.
To investigate the clinicopathological characteristics and survival outcomes of breast cancer in the male population, 8,607 cases of patients were identified in the Surveillance, Epidemiology, and End Results (SEER) database, including white males ( = 7122), black males ( = 1111), and other males (American Indian/AK Native, Asian/Pacific Islander) ( = 374). Black male breast cancer patients were more likely to be in stages II-IV and have more advanced tumors. The rate of lymph node (LN) involvement at diagnosis was higher in black men than in whites and others. The ER- and PR-positive rates were lower in black men than in whites and others. The distant metastasis rate was higher in blacks than in whites and others. Furthermore, the overall survival (OR) rates and breast cancer-specific survival rates were significantly poorer in blacks than in whites and others (χ = 29.974, < 0.001; χ = 7.285, = 0.026, respectively). In a multivariate analysis, the results showed that race could also be a prognostic indicator ( < 0.001). Moreover, significant differences were also observed in OS among 1:1:1 matched white, black, and other groups ( < 0.001). Differences in outcomes may be partially explained by differences in tumor grades, LN status, and ER and PR status between the 3 groups. This study might provide insights into a better understanding of male breast cancer.
为了研究男性人群中乳腺癌的临床病理特征和生存结局，在监测、流行病学和最终结果（SEER）数据库中识别出8607例患者，包括白人男性（n = 7122）、黑人男性（n = 1111）和其他男性（美国印第安人/阿拉斯加原住民、亚洲人/太平洋岛民）（n = 374）。黑人男性乳腺癌患者更有可能处于II-IV期且肿瘤更晚期。黑人男性诊断时的淋巴结（LN）受累率高于白人和其他种族。黑人男性的雌激素受体（ER）和孕激素受体（PR）阳性率低于白人和其他种族。黑人的远处转移率高于白人和其他种族。此外，黑人的总生存率（OS）和乳腺癌特异性生存率明显低于白人和其他种族（χ² = 29.974，P < 0.001；χ² = 7.285，P = 0.026）。在多变量分析中，结果显示种族也可能是一个预后指标（P < 0.001）。此外，在1:1:1匹配的白人、黑人和其他组之间的OS也观察到显著差异（P < 0.001）。三组之间结局的差异可能部分由肿瘤分级、LN状态以及ER和PR状态的差异所解释。本研究可能为更好地理解男性乳腺癌提供见解。
