Department of Medical Science, University of Turin, 10126 Turin, Italy.
Int J Mol Sci. 2017 Oct 20;18(10):2200. doi: 10.3390/ijms18102200.
Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated inflammatory response, which can impair the microcirculation and lead to organ injury. Being at the crossroads between the immune system, clotting cascade, and endothelial cells, platelets seem to be an appealing central mediator and possible therapeutic target in sepsis. This review focuses on the pathogenic role of platelets in septic organ dysfunction in humans and animal models.
血小板在感染性疾病、炎症和免疫的病理生理学中的作用受到越来越多的关注。在脓毒症中，血小板计数低是疾病严重程度的一个众所周知的生物标志物，最近作者们还将注意力集中在血小板在多器官衰竭发病机制中的积极作用上。脓毒性休克的特征是炎症反应失调，这会损害微循环并导致器官损伤。血小板位于免疫系统、凝血级联和内皮细胞之间的交汇点，似乎是脓毒症中一个有吸引力的中心介质和可能的治疗靶点。这篇综述重点介绍了血小板在人类和动物模型脓毒症器官功能障碍中的致病作用。
