Takayasu Tatsunori, Yamamoto Hiroki, Ishida Yuko, Nosaka Mizuho, Kawaguchi Mariko, Kuninaka Yumi, Kimura Akihiko, Kondo Toshikazu
Forensic Toxicology Unit, Department of Forensic Medicine and Pathology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Japan.
Department of Forensic Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.
Leg Med (Tokyo). 2017 Nov;29:44-50. doi: 10.1016/j.legalmed.2017.10.002. Epub 2017 Oct 4.
We herein report a fatal intoxication case caused by the ingestion of the insecticides chlorpyrifos-methyl (CPFM) and fenitrothion (MEP). A 70-year-old man was found dead in his house and a cup containing a small amount of agricultural chemicals was on the table near his body. External and internal examinations revealed no injuries. In a gas chromatography-mass spectrometry (GC-MS) screening test, CPFM, MEP, and their metabolites, 3,5,6-trichloro-2-pyridinol (TCPY) and 3-methyl-4-nitrophenol (3MNP), respectively, were qualitatively detected in his stomach contents. The concentrations (µg/g) of CPFM, TCPY, MEP, and 3MNP in the extracts of each body fluid and organ tissue were assessed by GC-MS and were as follows: 27.8, 56.2, 17.2, and 2.82 (heart blood); 6.60, 42.9, 1.80, and 2.59 (peripheral blood); 0.0821, 45.9, 2,09, and 102 (urine); 21.4, 26.6, 76.2, and 3.83 (brain (frontal portion)); 16.1, 101, 9.67, and 1.26 (liver); 7.45, 101, 21.4, and 26.1 (right kidney); and 73,500, 9750, 232,000, and 1880 (stomach contents), respectively. Based on these results and autopsy findings, the cause of death was acute fatal intoxication by CPFM and MEP.
我们在此报告一例因摄入杀虫剂甲基毒死蜱（CPFM）和杀螟硫磷（MEP）导致的致命中毒病例。一名70岁男性被发现死于家中，其尸体附近的桌子上有一个装有少量农用化学品的杯子。尸检未发现外伤。在气相色谱 - 质谱联用（GC - MS）筛查测试中，在其胃内容物中定性检测到了CPFM、MEP及其代谢产物，分别为3,5,6 - 三氯 - 2 - 吡啶醇（TCPY）和3 - 甲基 - 4 - 硝基苯酚（3MNP）。通过GC - MS评估了各体液和器官组织提取物中CPFM、TCPY、MEP和3MNP的浓度（μg/g），结果如下：心脏血液中分别为27.8、56.2、17.2和2.82；外周血中分别为6.60、42.9、1.80和2.59；尿液中分别为0.0821、45.9、2.09和102；脑（额叶部分）中分别为21.4、26.6、76.2和3.83；肝脏中分别为16.1、101、9.67和1.26；右肾中分别为7.45、101、21.4和26.1；胃内容物中分别为73500、9750、232000和1880。基于这些结果和尸检发现，死亡原因是CPFM和MEP引起的急性致命中毒。
