Pabalan Noel, Chaisri Suwit, Tabunhan Sompong, Phumyen Achara, Jarjanazi Hamdi, Steiner Theodore S
Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Acta Trop. 2018 Jan;177:186-193. doi: 10.1016/j.actatropica.2017.10.017. Epub 2017 Oct 18.
Dengue virus entry into a host is associated with a cell surface protein, DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin). A common CD209-336G/A (rs4804803) polymorphism in DC-SIGN may affect severity of dengue virus infection (DEN) and incidence of dengue fever (DF) or the more severe dengue hemorrhagic fever (DHF). However, the reported associations of these two outcomes and CD-209 have been inconsistent, which prompted a meta-analysis to obtain more precise estimates.
A literature search yielded seven case-control studies. We calculated pooled odds ratios (OR) and 95% confidence intervals using standard genetic models. Outlier treatment examined sources of potential heterogeneity. Subgroup analysis was performed for ethnicity and age.
All significant outcomes for association indicating reduced risk were pegged at P=0.007-0.05. In the homozygous and recessive models, these were observed in the overall analysis (OR 0.52-0.55), and subgroups of South/Central Americans (OR 0.30-0.32) and school-age children (OR 0.44) in the DHF analysis as well as the codominant model among Asians in DF (OR 0.59). These significant outcomes are strengthened by their non-heterogeneity (P>0.10) and robustness of the effects. Most pooled effects in DF and DEN were variable.
The DC-SIGN -336G/A polymorphism significantly affects DHF and DF incidence with the effect more pronounced in certain analyzed patient subgroups.
登革病毒进入宿主与一种细胞表面蛋白——树突状细胞特异性细胞间黏附分子-3结合非整合素（DC-SIGN）有关。DC-SIGN中常见的CD209-336G/A（rs4804803）多态性可能会影响登革病毒感染（DEN）的严重程度以及登革热（DF）或更严重的登革出血热（DHF）的发病率。然而，关于这两种结果与CD-209之间的关联报道并不一致，这促使我们进行一项荟萃分析以获得更精确的估计。
文献检索得到七项病例对照研究。我们使用标准遗传模型计算合并比值比（OR）和95%置信区间。离群值处理检查了潜在异质性的来源。对种族和年龄进行了亚组分析。
所有表明风险降低的关联显著结果的P值均为0.007 - 0.05。在纯合和隐性模型中，在总体分析中观察到这些结果（OR为0.52 - 0.55），在DHF分析中，南美/中美洲亚组（OR为0.30 - 0.32）和学龄儿童亚组（OR为0.44）以及DF中亚洲人的共显性模型（OR为0.59）中也观察到这些结果。这些显著结果因其非异质性（P>0.10）和效应的稳健性而得到加强。DF和DEN中的大多数合并效应是可变的。
DC-SIGN -336G/A多态性显著影响DHF和DF的发病率，在某些分析的患者亚组中这种影响更为明显。
