Christakos Sylvia
From the Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, the State University of New Jersey, New Jersey Medical School, Newark, New Jersey 07103
J Biol Chem. 2017 Oct 20;292(42):17559-17560. doi: 10.1074/jbc.H117.806901.
Although the cytochrome P450 CYP27B1 plays a critical role in vitamin D biology, the molecular mechanisms involved in regulation of CYP27B1 have remained undefined. A new study has identified a kidney-specific control module distal to the gene that mediates the basal activity and hormonal regulation of This work provides a novel mechanism indicating differential regulation of in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis and perhaps other autoimmune diseases as well.
尽管细胞色素P450 CYP27B1在维生素D生物学中发挥着关键作用，但参与CYP27B1调控的分子机制仍不明确。一项新研究确定了该基因远端的一个肾脏特异性控制模块，它介导了CYP27B1的基础活性和激素调节。这项工作提供了一种新机制，表明CYP27B1在肾细胞和非肾细胞中的调控存在差异，并且对多发性硬化症以及可能的其他自身免疫性疾病中的维生素D生物学具有重要意义。
