Gobbin F, Marangi A, Orlandi R, Richelli S, Turatti M, Calabrese M, Forgione A, Alessandrini F, Benedetti M D, Monaco S, Gajofatto A
Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy.
Unit of Intensive Rehabilitation, Ospedale Sacro Cuore, Negrar, Verona, Italy.
Mult Scler Relat Disord. 2017 Oct;17:9-11. doi: 10.1016/j.msard.2017.06.007. Epub 2017 Jun 20.
We describe the case of a woman who came to our attention for acute onset and very rapidly worsening left hemiplegia, vision loss and cognitive impairment. MRI, laboratory and clinical investigations were highly suggestive of an active inflammatory demyelinating disease. Following exclusion of other possible etiologies, a diagnosis of Marburg's variant multiple sclerosis was made. After repeated high-dose steroids and plasma-exchange, the patient was treated with a first course of alemtuzumab followed by improvement of the clinical and MRI picture. This is the first reported case of Marburg type multiple sclerosis treated with alemtuzumab.
我们描述了一名女性患者的病例，该患者因急性起病且左半身瘫痪、视力丧失和认知障碍迅速恶化而引起我们的关注。磁共振成像（MRI）、实验室检查和临床调查强烈提示为活动性炎性脱髓鞘疾病。在排除其他可能的病因后，诊断为马尔堡型多发性硬化症。在反复给予大剂量类固醇和进行血浆置换后，患者接受了第一疗程的阿仑单抗治疗，随后临床和MRI表现均有所改善。这是首例报道使用阿仑单抗治疗的马尔堡型多发性硬化症病例。
