Rossowski W J, Ertan A, Rice J, Ozden A, Covington S, McCord R
Tulane University School of Medicine, Department of Medicine, New Orleans, Louisiana 70112.
Am J Med Sci. 1988 Dec;296(6):399-405. doi: 10.1097/00000441-198812000-00006.
We present a comparative study of cholinergic muscarinic and somatostatin binding sites on isolated membranes from mucosa and tunica muscularis of normal and dilated parts of the proximal jejunum obtained at surgery from a patient with idiopathic intestinal pseudo-obstruction (IIP) syndrome. We found a statistically significant diminution of cholinergic muscarinic and somatostatin binding sites in mucosa taken from the dilated part of the jejunum, compared with those taken from the normal part. Tunica muscularis of the dilated part of the jejunum contained a significantly higher concentration of peripheral cholinergic muscarinic binding sites (M2) than the normal part did, whereas concentration of M1 cholinergic muscarinic and somatostatin binding sites was similar in both examined parts. These results indicate that IIP-syndrome may be related to alterations in cholinergic muscarinic binding sites in the tunica muscularis of the intestine.
我们对一名特发性肠假性梗阻（IIP）综合征患者手术获取的近端空肠正常及扩张部位的黏膜和肌层分离膜上的胆碱能毒蕈碱和生长抑素结合位点进行了一项比较研究。我们发现，与取自正常部位的空肠黏膜相比，取自扩张部位空肠黏膜的胆碱能毒蕈碱和生长抑素结合位点在统计学上有显著减少。空肠扩张部位的肌层所含外周胆碱能毒蕈碱结合位点（M2）的浓度明显高于正常部位，而在两个检查部位，M1胆碱能毒蕈碱和生长抑素结合位点的浓度相似。这些结果表明，IIP综合征可能与肠道肌层中胆碱能毒蕈碱结合位点的改变有关。
