Nowack W J, Johnson R N, Hanna G R
Department of Neurology, University of Arkansas for Medical Sciences, Little Rock 72205.
Neurol Res. 1988 Sep;10(3):156-60. doi: 10.1080/01616412.1988.11739834.
The thalamocortical augmenting response is a complex multineuronal response which can be elicited by repetitive stimulation of the ventrolateral thalamus. A major function of the ventrolateral thalamus is known to be a result of its participation in central nervous system activity related to motor behaviour. The significance of the thalamocortical augmenting response itself is not known. Since it would be reasonable to relate that response to motor behaviour, we evaluated the effect on the thalamocortical augmenting response of the stimulation of two other central nervous system structures which are also thought to participate in motor control, the cerebellum and the red nucleus. We conclude that at least part of the effect of red nucleus stimulation on the thalamocortical augmenting response is exerted through a rubro-olivo-cerebellar pathway. We then compared the effects of red nucleus and of cerebellar stimulation to the effect of stimulating a non-motor mesencephalic site, the periaqueductal gray. The changes induced in the thalamocortical augmenting response appear not to be fully explicable solely in terms of changes in motor behaviour.
丘脑皮质增强反应是一种复杂的多神经元反应，可通过反复刺激丘脑腹外侧核诱发。已知丘脑腹外侧核的一个主要功能是其参与与运动行为相关的中枢神经系统活动的结果。丘脑皮质增强反应本身的意义尚不清楚。由于将该反应与运动行为联系起来是合理的，我们评估了刺激另外两个也被认为参与运动控制的中枢神经系统结构——小脑和红核——对丘脑皮质增强反应的影响。我们得出结论，红核刺激对丘脑皮质增强反应的影响至少部分是通过红核-橄榄-小脑通路发挥作用的。然后，我们将红核和小脑刺激的效果与刺激中脑非运动部位导水管周围灰质的效果进行了比较。丘脑皮质增强反应中诱导的变化似乎不能仅根据运动行为的变化来完全解释。
