Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical University, Xuzhou, 221002, China.
Department of Urinary Surgery, The Affiliated Hospital of University Medical College, Xuzhou, 221000, China.
Clin Transl Oncol. 2018 May;20(5):570-575. doi: 10.1007/s12094-017-1774-3. Epub 2017 Oct 20.
Ki67 is a well-known proliferation marker for the evaluation of cell proliferation. Numerous studies have indicated that Ki67 index independently predicts cancer progression. Moreover, because Ki67 is highly expressed in malignant cells but almost could not be detected in normal cells, it has become a promising target for cancer therapy. In this review, we summarize recent advances in Ki67 targeted cancer therapy. In particular, we highlight recent development on the exploitation of Ki67 promoter to drive the expression of siRNAs or therapeutic genes in cancer cells specifically. The use of Ki67 as an attractive target opens a new avenue for cancer therapy.
Ki67 是评估细胞增殖的一种著名的增殖标志物。许多研究表明，Ki67 指数独立预测癌症进展。此外，由于 Ki67 在恶性细胞中高度表达，但在正常细胞中几乎检测不到，因此它已成为癌症治疗的有前途的靶点。在这篇综述中，我们总结了 Ki67 靶向癌症治疗的最新进展。特别是，我们强调了最近利用 Ki67 启动子在癌细胞中特异性驱动 siRNA 或治疗基因表达的研究进展。将 Ki67 用作有吸引力的靶标为癌症治疗开辟了新途径。
