β-肾上腺素能受体激动剂对肺泡巨噬细胞悬液中过氧化氢生成的影响并非由β-受体介导。
The effects of beta-adrenergic receptor agonists on the H2O2 formation in alveolar macrophage suspensions are not mediated by beta-receptors.
作者信息
Goeptar A R, Haenen G R, Timmerman H, Bast A
机构信息
Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands.
出版信息
Agents Actions. 1988 Dec;25(3-4):375-7. doi: 10.1007/BF01965045.
In the present study, the effects of beta-adrenergic receptor agonists on the hydrogen peroxide (H2O2) production in phorbol myristate acetate stimulated guinea pig alveolar macrophage suspensions have been investigated. In contrast to suggestions described in literature, our results indicate that the H2O2 production in alveolar macrophage suspensions is not mediated by beta-adrenergic receptors. Rather, it is suggested that the inhibitory effect of catecholamines in the H2O2 formation which is found after 5 minutes is the result of inhibition of the horseradish peroxidase catalysed phenol red oxidation, used as H2O2 measurement, by the catecholamines.
在本研究中，已对β-肾上腺素能受体激动剂对佛波酯刺激的豚鼠肺泡巨噬细胞悬液中过氧化氢（H₂O₂）生成的影响进行了研究。与文献中所述的观点相反，我们的结果表明，肺泡巨噬细胞悬液中H₂O₂的生成不是由β-肾上腺素能受体介导的。相反，有人提出，5分钟后发现的儿茶酚胺对H₂O₂形成的抑制作用是儿茶酚胺抑制用作H₂O₂测量的辣根过氧化物酶催化的酚红氧化的结果。
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