Wang Bo, Abbott Laura, Childs Kate, Taylor Chris, Agarwal Kosh, Cormack Ian, Miquel Rosa, Suddle Abid
1 Institute of Liver Studies, King's College Hospital, London, UK.
2 Department of Genitourinary Medicine and HIV, 156767 Croydon University Hospital , Croydon, UK.
Int J STD AIDS. 2018 Mar;29(4):414-417. doi: 10.1177/0956462417734099. Epub 2017 Oct 23.
A patient with human immunodeficiency virus-1 infection presented with sub-acute liver failure, temporally related to commencement of an antiretroviral therapy regimen containing dolutegravir (Triumeq). The patient was not a carrier of HLA-B5701, and abacavir hypersensitivity was unlikely. We believe this is the first report of severe dolutegravir-related hepatotoxicity resulting in sub-acute liver failure and transplantation and highlights a potential need for closer monitoring after drug initiation.
一名感染人类免疫缺陷病毒1型的患者出现亚急性肝衰竭，时间上与开始使用包含多替拉韦（绥美凯）的抗逆转录病毒治疗方案相关。该患者不是HLA - B5701携带者，阿巴卡韦超敏反应可能性不大。我们认为这是首例因多替拉韦相关严重肝毒性导致亚急性肝衰竭并进行肝移植的报告，强调了在药物起始后可能需要更密切监测。
