Michaeli Y, Zajicek G, Weinreb M
J Biol Buccale. 1979 Sep;7(3):243-9.
74 rat incisor odontogenic organs were autotransplanted intradermally into the auricle. The animals were killed in groups of four up to eight months after grafting. Out of 61 grafts examined from the third week onward, 46% exhibited a typical odontogenic organ or a well differentiated tooth with pulp, vessels and nerve fibers. In 33% only scattered epithelial islands were formed. 21% of the grafts ended as osteodentin. Following the initial trauma leading to aseptic necrosis, the most primitive odontogenic organ cells survive to generate a new tooth. The grafted odontogenic organ resumes its existence as a complex structure which mobilizes its own vascular and nervous supply from the host dermis as evident from nerve fibers which penetrated the tooth pulp. Since all original nerve fibers of the graft had to be disconnected from their cell bodies, they obviously degenerated. Thus any nerve fiber observed in the regenerating tooth pulp had to be of dermal origin.
将74个大鼠切牙牙源性器官皮内自体移植到耳廓。在移植后长达8个月的时间里，将动物分成每组4只进行处死。从第三周起检查的61个移植物中，46%表现出典型的牙源性器官或具有牙髓、血管和神经纤维的分化良好的牙齿。33%仅形成散在的上皮岛。21%的移植物最终形成骨牙本质。在导致无菌性坏死的初始创伤后，最原始的牙源性器官细胞存活下来以生成一颗新牙。移植的牙源性器官作为一个复杂结构恢复其存在，从宿主真皮动员自身的血管和神经供应，这从穿透牙髓的神经纤维可以明显看出。由于移植物的所有原始神经纤维都必须与其细胞体断开连接，它们显然发生了退化。因此，在再生牙髓中观察到的任何神经纤维都必须来自真皮。
