School of Anatomy, Human Biology and Physiology, University of Western Australia, Crawley, WA, Australia.
Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Oncogene. 2018 Feb 15;37(7):833-838. doi: 10.1038/onc.2017.406. Epub 2017 Oct 23.
Breast cancer pathobiology is known to be influenced by the differential expression of a group of proteins called the kinesin superfamily (KIFs), which is instrumental in the intracellular transport of chromosomes along microtubules during mitosis. During cellular division, kinesins are strictly regulated through temporal synthesis so that they are present only when needed. However, their misregulation may contribute to uncontrolled cell growth owing to premature sister chromatid separation, highlighting their importance in cancer. This review covers the functions of kinesins in normal and breast cancer cells, the use of kinesins for breast cancer patient prognosis, and the targeting of these molecules for therapeutics. A better understanding of KIF proteins may be pivotal to improved disease outcomes for breast cancer patients.
乳腺癌的病理生物学已知受到一组称为驱动蛋白超家族 (KIFs) 的蛋白质的差异表达的影响，该家族在有丝分裂期间沿着微管对染色体的细胞内运输至关重要。在细胞分裂过程中，通过时间合成严格调节驱动蛋白，以使它们仅在需要时存在。然而，由于姐妹染色单体过早分离，它们的失调可能导致不受控制的细胞生长，这凸显了它们在癌症中的重要性。本综述涵盖了驱动蛋白在正常和乳腺癌细胞中的功能、驱动蛋白在乳腺癌患者预后中的应用，以及针对这些分子的治疗靶向。更好地了解 KIF 蛋白可能对改善乳腺癌患者的疾病结局至关重要。
