Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas, USA.
Department of Psychology, The University of Texas at Austin, Austin, Texas, USA.
Am J Hypertens. 2017 Nov 1;30(11):1100-1105. doi: 10.1093/ajh/hpx108.
Arterial blood pressure (BP) can be divided into steady state component that is determined by mean arterial pressure and pulsatile component that is explored by pulse pressure (PP). We determined relationships between BP components and regional cerebral perfusion.
A total of 52 apparently healthy and cognitively normal adults aged 40-60 years were studied. Regional cerebral perfusion was measured using functional magnetic resonance imaging (MRI) arterial spin labeling technique in 10 a priori regions of interest.
There were 5 regions with cerebral perfusion values significantly associated with either pulsatile BP component (i.e., hippocampus, posterior insula, and central white matter) or both steady and pulsatile components (i.e., anterior white matter, and occipitoparietal area). After controlling for body mass index, education, age, and sex, associations between pulsatile BP components and regional cerebral perfusion remained significant in 2 regions (i.e., hippocampus and anterior white matter). Multiple linear regression analyses revealed that brachial systolic pressure (β = -0.35, P = 0.03) and PP (β = -0.36, P = 0.02) explained 11 and 12% of the variability in hippocampus perfusion, independent of the entered covariates.
The present preliminary study indicated that pulsatile component of BP was more strongly related to regional cerebral perfusion in areas susceptible to cerebrovascular diseases than steady state component.
动脉血压（BP）可分为由平均动脉压决定的稳态分量和由脉压（PP）探索的脉动分量。我们确定了 BP 分量与局部脑灌注之间的关系。
共纳入 52 名年龄在 40-60 岁之间的明显健康和认知正常的成年人进行研究。使用功能磁共振成像（MRI）动脉自旋标记技术，在 10 个预先设定的感兴趣区域测量局部脑灌注。
有 5 个区域的脑灌注值与脉动 BP 分量（即海马体、后岛叶和中央白质）或两者的稳态和脉动分量（即前白质和顶枕区）均有显著相关性。在校正体重指数、教育程度、年龄和性别后，脉动 BP 分量与 2 个区域（即海马体和前白质）的局部脑灌注之间的相关性仍然显著。多元线性回归分析显示，肱动脉收缩压（β=-0.35，P=0.03）和脉压（β=-0.36，P=0.02）分别解释了海马体灌注变化的 11%和 12%，独立于纳入的协变量。
本初步研究表明，BP 的脉动分量与易发生脑血管疾病的区域的局部脑灌注的关系比稳态分量更强。
